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NCT03226847 · ClinicalTrials.gov registry record · NA
Pulmonary Vein Isolation in Athletes
A NA study, sponsored by The Cleveland Clinic.
- Completed
- Registry status
- NA
- Development phase
- 10
- Enrollment target
NCT03226847: Completed NA study, sponsored by The Cleveland Clinic.
NCT03226847 is a NA study that has completed, run by The Cleveland Clinic. The registered enrollment target is 10 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03226847, a NA study, has completed, sponsored by The Cleveland Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
Study Summary
Pulmonary vein isolation (PVI) has become a common and effective treatment for paroxysmal and persistent atrial fibrillation (AF), particularly in patients with drug-refractory disease. Intense endurance exercise is a known risk factor for atrial fibrillation. In general, these athletes poorly tolerate most common antiarrhythmic drugs used for atrial fibrillation control and often PVI is recommended for durable management. While the efficacy of PVI in athletes is similar to the general AF population, some athletes with lone atrial fibrillation report a reduction in subjective exertional capacity following PVI, despite maintenance of sinus rhythm and absence of pulmonary vein stenosis on imaging. The investigators hypothesize that PVI may alter pulmonary vein function and affect peak exercise performance. The investigators propose a small, prospective study of endurance athletes undergoing antral PVI for treatment of lone atrial fibrillation. Peak metabolic performance and pulmonary vein function will be assessed pre- and post-PVI by metabolic stress testing and cardiac MRI, respectively.
Primary Outcome
Assessed by cardiopulmonary stress testing
Interventions
- PROCEDURE Pulmonary Vein Isolation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2017-07-17 |
| Est. Completion | 2021-03-16 |
| Phase | NA |
What the finished NCT03226847 record still lists
NCT03226847 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which Pulmonary Vein Isolation is the first listed.
NCT03226847 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03226847 about?
NCT03226847 is a clinical study titled "Pulmonary Vein Isolation in Athletes". Pulmonary vein isolation (PVI) has become a common and effective treatment for paroxysmal and persistent atrial fibrillation (AF), particularly in patients with drug-refractory disease. Intense endurance exercise is a known risk factor for atrial fibrillation. In general, these athletes poorly toler...
What is the current status of trial NCT03226847?
This trial is currently completed. It is a NA study. The enrollment target is 10 participants. The study started on 2017-07-17. Estimated completion is 2021-03-16.
What interventions are being tested in trial NCT03226847?
The interventions under investigation include: Pulmonary Vein Isolation (PROCEDURE).
Who is sponsoring clinical trial NCT03226847?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03226847's enrollment target sits among peer trials
10 1927th of 2000 higher than 26 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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