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NCT03224988 · ClinicalTrials.gov registry record
Bilateral Brain Dynamics in Cognition and Aging
A clinical trial, sponsored by Duke University.
- Completed
- Registry status
- 30
- Enrollment target
NCT03224988 is a clinical trial that has completed, run by Duke University. The registered enrollment target is 30 participants.
The verdict
NCT03224988 has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- 30 participants
- Enrollment target
Study Summary
This project is focused on the gap in understanding of bilateral brain interactions and their role in helping normative and clinical elderly populations maintain cognitive health. The investigator will focus on investigating this neural mechanism of these interactions and promoting them with a precise application of TMS, in order to test the hypothesis that excitatory interactions between the hemispheres can provide positive outcomes for patients with pre-clinical AD (amnestic Mild Cognitive Impairment or MCI-AD). In Session 1, the investigator will establish the spatial specificity of bilateral brain mechanisms with combination of behavior, TMS, and structural neuroimaging in cortical sites known to be active during memory encoding. In Session 2, the investigator will establish the underlying dynamics of interhemispheric communication using a novel combination of TMS and electroencephalography (EEG) to establish the coordinated activity between the hemispheres; Lastly, in Session 3, the investigator will use the TMS entraining parameters delineated in Aim 2 to promote specific cross-hemispheric communication, applied to participants performing a Picture Encoding task, a general task of memory performance. The outcome of these studies will allow our group to evaluate the strength of this brain stimulation protocol in alleviating age-related and dementia-related cognitive decline, and enable development of novel treatment protocols for dementia in elderly cohorts.
Interventions
- DEVICE TMS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2018-03-20 |
| Est. Completion | 2022-01-20 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03224988
The ClinicalTrials.gov registry entry for NCT03224988 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which TMS is the first listed.
NCT03224988 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03224988 about?
NCT03224988 is a clinical study titled "Bilateral Brain Dynamics in Cognition and Aging". This project is focused on the gap in understanding of bilateral brain interactions and their role in helping normative and clinical elderly populations maintain cognitive health. The investigator will focus on investigating this neural mechanism of these interactions and promoting them with a preci...
What is the current status of trial NCT03224988?
This trial is currently completed. The enrollment target is 30 participants. The study started on 2018-03-20. Estimated completion is 2022-01-20.
What interventions are being tested in trial NCT03224988?
The interventions under investigation include: TMS (DEVICE).
Who is sponsoring clinical trial NCT03224988?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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