Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03193216 · ClinicalTrials.gov registry record · Phase 2
The Impact of Adjuvant Liquid Alginate on Endoscopic Ablation Therapy of Complicated Barrett's Esophagus
A Phase 2 study of Barretts Esophagus With Dysplasia, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- Phase 2
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT03193216: Completed Phase 2 study of Barretts Esophagus With Dysplasia, sponsored by Medical University of South Carolina.
NCT03193216 is a Phase 2 study of Barretts Esophagus With Dysplasia that has completed, run by Medical University of South Carolina. The registered enrollment target is 24 participants, below the 706-participant average among 5 other Barretts Esophagus With Dysplasia trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03193216, a Phase 2 study of Barretts Esophagus With Dysplasia, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
This study evaluates the addition of an alginate based solution to twice daily proton pump inhibitor therapy (PPI) in patients undergoing ablative therapy for dysplastic Barrett's esophagus. The investigators hypothesize that the addition of this medication will help to achieve complete remission of Barrett's over a shorter period of time.
Primary Outcome
To compare the percentage of patients who achieved complete endoscopic eradication of dysplastic Barrett's Esophagus(BE) and non-dysplastic BE with the combination of PPI and liquid alginate solution vs. those treated with PPI alone within eighteen months from the start of treatment.
Conditions Studied
Interventions
- DRUG Alginates
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2017-08-25 |
| Est. Completion | 2022-01-01 |
| Phase | Phase 2 |
What the finished NCT03193216 record still lists
NCT03193216 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 706-participant average among 5 other Barretts Esophagus With Dysplasia trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Barretts Esophagus With Dysplasia appearing as the primary indexed condition, and to 1 intervention - of which Alginates is the first listed.
NCT03193216 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT03193216 about?
NCT03193216 is a clinical study titled "The Impact of Adjuvant Liquid Alginate on Endoscopic Ablation Therapy of Complicated Barrett's Esophagus". This study evaluates the addition of an alginate based solution to twice daily proton pump inhibitor therapy (PPI) in patients undergoing ablative therapy for dysplastic Barrett's esophagus. The investigators hypothesize that the addition of this medication will help to achieve complete remission of...
What is the current status of trial NCT03193216?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 24 participants. The study started on 2017-08-25. Estimated completion is 2022-01-01.
What conditions does trial NCT03193216 study?
This clinical trial studies the following conditions: Barretts Esophagus With Dysplasia.
What interventions are being tested in trial NCT03193216?
The interventions under investigation include: Alginates (DRUG).
Who is sponsoring clinical trial NCT03193216?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03193216 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Barretts Esophagus With Dysplasia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples
RECRUITING · NA
-
Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance
RECRUITING · NA
-
Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia
RECRUITING · NA
-
Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy
ACTIVE NOT RECRUITING
-
Characterization of the Neo-squamous Epithelial Barrier
COMPLETED
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02331979 · 24 participants · NA
Improving Bladder Function in SCI by Neuromodulation
- NCT03096197 · 24 participants · NA
Exoskeleton and Spinal Cord Stimulation for SCI
- NCT03223922 · 24 participants · NA
Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases
- NCT03326921 · 24 participants · Phase 1
HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI