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NCT03173456 · ClinicalTrials.gov registry record · Phase 2
Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)
A Phase 2 study, sponsored by Albert Einstein College of Medicine.
- Completed
- Registry status
- Phase 2
- Development phase
- 600
- Enrollment target
NCT03173456: Completed Phase 2 study, sponsored by Albert Einstein College of Medicine.
NCT03173456 is a Phase 2 study that has completed, run by Albert Einstein College of Medicine. The registered enrollment target is 600 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (351% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03173456, a Phase 2 study, has completed, sponsored by Albert Einstein College of Medicine.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 600 participants
- Enrollment target
Study Summary
This study compares the efficacy of five oral analgesics: 5 mg oxycodone + 325 mg acetaminophen, 5 mg hydrocodone + 300 mg acetaminophen, 30 mg codeine + 300 mg acetaminophen, 400 mg ibuprofen + 1000 mg acetaminophen, and 800 mg ibuprofen + 1000 mg acetaminophen for the treatment of patients with acute musculoskeletal pain who present to the Emergency Department (ED).
Primary Outcome
Pain intensity measured by 11-point Numerical Rating Scale (NRS) of Pain 0 = no pain 10 = worse possible pain. Change calculated as NRS before medication administered (denoted as baseline) minus NRS 1-hour post-baseline. Higher scores mean more change which is the better outcome.
Interventions
- DRUG hydrocodone/APAP
- DRUG oxycodone/APAP
- DRUG codeine/APAP
- DRUG 400 ibuprofen/APAP
- DRUG 800 ibuprofen/APAP
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2017-11-28 |
| Est. Completion | 2019-11-14 |
| Phase | Phase 2 |
What the finished NCT03173456 record still lists
NCT03173456 is an interventional study that assigns participants to a tested intervention. The registered 600 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (351% higher).
The record links to 0 conditions, and to 5 interventions - of which hydrocodone/APAP is the first listed.
NCT03173456 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03173456 about?
NCT03173456 is a clinical study titled "Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)". This study compares the efficacy of five oral analgesics: 5 mg oxycodone + 325 mg acetaminophen, 5 mg hydrocodone + 300 mg acetaminophen, 30 mg codeine + 300 mg acetaminophen, 400 mg ibuprofen + 1000 mg acetaminophen, and 800 mg ibuprofen + 1000 mg acetaminophen for the treatment of patients with ac...
What is the current status of trial NCT03173456?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 600 participants. The study started on 2017-11-28. Estimated completion is 2019-11-14.
What interventions are being tested in trial NCT03173456?
The interventions under investigation include: hydrocodone/APAP (DRUG), oxycodone/APAP (DRUG), codeine/APAP (DRUG), 400 ibuprofen/APAP (DRUG), 800 ibuprofen/APAP (DRUG).
Who is sponsoring clinical trial NCT03173456?
This trial is sponsored by Albert Einstein College of Medicine, which has 175 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03173456's enrollment target sits among peer trials
600 53rd of 2000 higher than 1,945 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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