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NCT03142919 · ClinicalTrials.gov registry record · Phase 1
Lipopolysaccharide (LPS) Challenge in Depression
A Phase 1 study, sponsored by Laureate Institute for Brain Research.
- Completed
- Registry status
- Phase 1
- Development phase
- 64
- Enrollment target
NCT03142919: Completed Phase 1 study, sponsored by Laureate Institute for Brain Research.
NCT03142919 is a Phase 1 study that has completed, run by Laureate Institute for Brain Research. The registered enrollment target is 64 participants, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03142919, a Phase 1 study, has completed, sponsored by Laureate Institute for Brain Research.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 64 participants
- Enrollment target
Study Summary
LPS Challenge in Individuals with Major Depressive Disorder
Primary Outcome
The SHAPS is a 14-item self-administered questionnaire, with each item scored from 1-4 (strongly agree through strongly disagree; range 14-56), with higher scores indicating greater anticipatory, not consummatory, anhedonia. Disagreement (i.e. score of 3 or 4) on at least three items is defined as indicating clinically significant anhedonia.
Interventions
- BIOLOGICAL Placebo
- BIOLOGICAL Lipopolysaccharide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 64 participants |
| Start Date | 2017-09-07 |
| Est. Completion | 2020-12-01 |
| Phase | Phase 1 |
What the finished NCT03142919 record still lists
NCT03142919 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 64 participants, a relatively small participant target, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT03142919 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03142919 about?
NCT03142919 is a clinical study titled "Lipopolysaccharide (LPS) Challenge in Depression". LPS Challenge in Individuals with Major Depressive Disorder
What is the current status of trial NCT03142919?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 64 participants. The study started on 2017-09-07. Estimated completion is 2020-12-01.
What interventions are being tested in trial NCT03142919?
The interventions under investigation include: Placebo (BIOLOGICAL), Lipopolysaccharide (BIOLOGICAL).
Who is sponsoring clinical trial NCT03142919?
This trial is sponsored by Laureate Institute for Brain Research, which has 45 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03142919's enrollment target sits among peer trials
64 808th of 2000 higher than 1,181 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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