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NCT03141021 · ClinicalTrials.gov registry record
Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors
A clinical trial of Malignant Peripheral Nerve Sheath Tumors, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- 1,050
- Enrollment target
- 13
- Study locations
NCT03141021 is a study of Malignant Peripheral Nerve Sheath Tumors that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 1,050 participants, above the 460-participant average among 3 other Malignant Peripheral Nerve Sheath Tumors trials with a reported enrollment target (128% higher). The trial reports 13 study locations across 11 states.
The verdict
NCT03141021, a study of Malignant Peripheral Nerve Sheath Tumors, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- 1,050 participants
- Enrollment target
- 13
- Study locations
Study Summary
First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers. Although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the INFACT effort outcome. This registry would then allow the acquisition of data associated with MPNST biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue DNA) samples, and any previously somatic whole-exome or whole-genome sequencing data for aggregate analyses). Second, the investigators plan to co-register patients to institutional banks in order to prospectively collect MPNST samples for analysis. These patients will be consented in order to collect the above information and for banking of tumor tissue and future studies that include genomic characterization of the tumors.
Conditions Studied
Study Locations (13)
Maryland
- Johns Hopkins - Baltimore
- National Institutes of Health (NIH) - Bethesda
Other
- Global Gene Corporation - Mumbai
- Royal National Orthopedic Hospital - London
Florida
- Moffitt Cancer Center - Tampa
Massachusetts
- Dana Farber Cancer Institute - Boston
Minnesota
- University of Minnesota - Minneapolis
Missouri
- Washington University School of Medicine - St Louis
New York
- Memorial Sloan Kettering Cancer Center - New York
Rhode Island
- Lifespan - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,050 participants |
| Start Date | 2017-04-28 |
| Est. Completion | 2053-04-30 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03141021
The ClinicalTrials.gov registry entry for NCT03141021 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 1,050 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 460-participant average among 3 other Malignant Peripheral Nerve Sheath Tumors trials with a reported enrollment target (128% higher). The listed sponsor is Washington University School of Medicine, which has 1,502 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Malignant Peripheral Nerve Sheath Tumors appearing as the primary indexed condition, and to 0 interventions.
NCT03141021 reports 13 study locations spanning 11 distinct geographic areas - top geographies include Maryland, Other, Florida.
Frequently Asked Questions
What is clinical trial NCT03141021 about?
NCT03141021 is a clinical study titled "Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors". First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established,...
What is the current status of trial NCT03141021?
This trial is currently recruiting. The enrollment target is 1,050 participants. The study started on 2017-04-28. Estimated completion is 2053-04-30.
What conditions does trial NCT03141021 study?
This clinical trial studies the following conditions: Malignant Peripheral Nerve Sheath Tumors.
Who is sponsoring clinical trial NCT03141021?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03141021 being conducted?
This trial has 13 study locations across Florida, Maryland, Massachusetts, Minnesota, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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