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Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors
NCT03141021 · View on ClinicalTrials.gov ↗
Study Summary
First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers. Although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the INFACT effort outcome. This registry would then allow the acquisition of data associated with MPNST biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue DNA) samples, and any previously somatic whole-exome or whole-genome sequencing data for aggregate analyses). Second, the investigators plan to co-register patients to institutional banks in order to prospectively collect MPNST samples for analysis. These patients will be consented in order to collect the above information and for banking of tumor tissue and future studies that include genomic characterization of the tumors.
Conditions Studied
Study Locations (13)
Maryland
- Johns Hopkins — Baltimore
- National Institutes of Health (NIH) — Bethesda
Other
- Global Gene Corporation — Mumbai
- Royal National Orthopedic Hospital — London
Florida
- Moffitt Cancer Center — Tampa
Massachusetts
- Dana Farber Cancer Institute — Boston
Minnesota
- University of Minnesota — Minneapolis
Missouri
- Washington University School of Medicine — St Louis
New York
- Memorial Sloan Kettering Cancer Center — New York
Rhode Island
- Lifespan — Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,050 participants |
| Start Date | 2017-04-28 |
| Est. Completion | 2053-04-30 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03141021
The ClinicalTrials.gov registry entry for NCT03141021 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,050 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Washington University School of Medicine, which has 1,036 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Malignant Peripheral Nerve Sheath Tumors appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03141021 reports 13 study locations spanning 11 distinct geographic areas — top geographies include Maryland, Other, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03141021 about?
NCT03141021 is a clinical study titled "Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors". First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established,...
What is the current status of trial NCT03141021?
This trial is currently recruiting. The enrollment target is 1,050 participants. The study started on 2017-04-28. Estimated completion is 2053-04-30.
What conditions does trial NCT03141021 study?
This clinical trial studies the following conditions: Malignant Peripheral Nerve Sheath Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT03141021?
This trial is sponsored by Washington University School of Medicine, which has 1,036 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03141021 being conducted?
This trial has 13 study locations across Florida, Maryland, Massachusetts, Minnesota, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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