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NCT03126682 · ClinicalTrials.gov registry record · Phase 4
Effect of Bupropion on Seizure Threshold in Depressed Patients
A Phase 4 study, sponsored by Duke University.
- Completed
- Registry status
- Phase 4
- Development phase
- 10
- Enrollment target
NCT03126682: Completed Phase 4 study, sponsored by Duke University.
NCT03126682 is a Phase 4 study that has completed, run by Duke University. The registered enrollment target is 10 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03126682, a Phase 4 study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 10 participants
- Enrollment target
Study Summary
The purpose of the study is to examine the effect of bupropion on seizure threshold and duration in depressed patients receiving right unilateral ultra-brief electroconvulsive therapy (ECT). The investigators plan to recruit 10 patients into the study, administer sustained release (SR) bupropion 4 hours prior to receiving ECT. The investigators plan to compare the seizure threshold and seizure durations between ECT sessions with and without bupropion administration. The study's implication is to examine how ECT can be optimized by rational combination with medications that lower seizure threshold.
Primary Outcome
Charge in Millicoulombs at which subject gets a seizure with ECT. First measurement on day 1 of electroconvulsive treatment (ECT) and second measurement on day 2 of electroconvulsive therapy (ECT), separated by 1 day interval. This outcome measure was not measured at baseline.
Interventions
- DRUG Wellbutrin SR 300Mg Extended-Release Tablet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2017-08-25 |
| Est. Completion | 2018-05-31 |
| Phase | Phase 4 |
What the finished NCT03126682 record still lists
NCT03126682 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which Wellbutrin SR 300Mg Extended-Release Tablet is the first listed.
NCT03126682 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03126682 about?
NCT03126682 is a clinical study titled "Effect of Bupropion on Seizure Threshold in Depressed Patients". The purpose of the study is to examine the effect of bupropion on seizure threshold and duration in depressed patients receiving right unilateral ultra-brief electroconvulsive therapy (ECT). The investigators plan to recruit 10 patients into the study, administer sustained release (SR) bupropion 4 h...
What is the current status of trial NCT03126682?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 10 participants. The study started on 2017-08-25. Estimated completion is 2018-05-31.
What interventions are being tested in trial NCT03126682?
The interventions under investigation include: Wellbutrin SR 300Mg Extended-Release Tablet (DRUG).
Who is sponsoring clinical trial NCT03126682?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03126682's enrollment target sits among peer trials
10 1940th of 2000 higher than 33 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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