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NCT03081416 · ClinicalTrials.gov registry record · Phase 3
"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"
A Phase 3 study, sponsored by Brooke Army Medical Center.
- Completed
- Registry status
- Phase 3
- Development phase
- 80
- Enrollment target
NCT03081416: Completed Phase 3 study, sponsored by Brooke Army Medical Center.
NCT03081416 is a Phase 3 study that has completed, run by Brooke Army Medical Center. The registered enrollment target is 80 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (90% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03081416, a Phase 3 study, has completed, sponsored by Brooke Army Medical Center.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 80 participants
- Enrollment target
Study Summary
This is a randomized, single-blind, placebo controlled trial to evaluate the efficacy of sub-dissociative dose ketamine versus standard care therapy for acute headache management of in patients presenting to the emergency department with headache as the chief compliant.
Primary Outcome
Change in Visual Analogue Score at 30 minutes
Interventions
- DRUG Ketamine
- DRUG Ketorolac
- DRUG Dexamethasone
- DRUG Normal saline
- DRUG Metoclopramide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2016-05 |
| Est. Completion | 2017-10 |
| Phase | Phase 3 |
What the finished NCT03081416 record still lists
NCT03081416 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (90% lower).
The record links to 0 conditions, and to 5 interventions - of which Ketamine is the first listed.
NCT03081416 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03081416 about?
NCT03081416 is a clinical study titled ""THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"". This is a randomized, single-blind, placebo controlled trial to evaluate the efficacy of sub-dissociative dose ketamine versus standard care therapy for acute headache management of in patients presenting to the emergency department with headache as the chief compliant.
What is the current status of trial NCT03081416?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 80 participants. The study started on 2016-05. Estimated completion is 2017-10.
What interventions are being tested in trial NCT03081416?
The interventions under investigation include: Ketamine (DRUG), Ketorolac (DRUG), Dexamethasone (DRUG), Normal saline (DRUG), Metoclopramide (DRUG).
Who is sponsoring clinical trial NCT03081416?
This trial is sponsored by Brooke Army Medical Center, which has 54 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03081416's enrollment target sits among peer trials
80 1755th of 2000 higher than 233 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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