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NCT03067584 · ClinicalTrials.gov registry record
Genetic Study of Familial Acute Lymphoblastic Leukemia
A clinical trial, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- 4
- Enrollment target
NCT03067584: Completed study, sponsored by St. Jude Children's Research Hospital.
NCT03067584 is a clinical trial that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 4 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03067584 has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- 4 participants
- Enrollment target
Study Summary
Familial aggregation is well recognized in some cancers. Though a number of familial cancer predisposition syndromes have been described, the nature of inherited genetic alterations in patients with a strong history of familial cancer is currently unknown, as is the case with childhood acute lymphoblastic leukemia (ALL). The investigators are seeking to learn more about what causes leukemia and why some people and families may be at a higher risk of developing this disease. By understanding the origin of the disease, better treatments may be identified for patients with leukemia. PRIMARY OBJECTIVE: To identify variants in genes that are inherited, have altered gene structure and/or function, and influence the risk of developing acute lymphoblastic leukemia (ALL) and other cancers. SECONDARY OBJECTIVE: To collect demographic, clinical and laboratory information including detailed family cancer history and response of cancers to therapy for correlation with the primary objective.
Primary Outcome
Probands and cancer affected and unaffected relatives from selected families will be sequenced using Whole Genome Sequencing (WGS) or possibly Whole Exome Sequencing (WES) and analyzed to identify new predisposing genetic variants that co-segregate with the tumor phenotype.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2017-05-09 |
| Est. Completion | 2017-06-23 |
What the finished NCT03067584 record still lists
NCT03067584 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 4 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT03067584 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03067584 about?
NCT03067584 is a clinical study titled "Genetic Study of Familial Acute Lymphoblastic Leukemia". Familial aggregation is well recognized in some cancers. Though a number of familial cancer predisposition syndromes have been described, the nature of inherited genetic alterations in patients with a strong history of familial cancer is currently unknown, as is the case with childhood acute lymphob...
What is the current status of trial NCT03067584?
This trial is currently completed. The enrollment target is 4 participants. The study started on 2017-05-09. Estimated completion is 2017-06-23.
Who is sponsoring clinical trial NCT03067584?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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