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NCT03039023 · ClinicalTrials.gov registry record · NA
Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans
A NA study, sponsored by The Cleveland Clinic.
- Completed
- Registry status
- NA
- Development phase
- 86
- Enrollment target
NCT03039023: Completed NA study, sponsored by The Cleveland Clinic.
NCT03039023 is a NA study that has completed, run by The Cleveland Clinic. The registered enrollment target is 86 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03039023, a NA study, has completed, sponsored by The Cleveland Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 86 participants
- Enrollment target
Study Summary
The investigators are interested in learning more about choline, a nutrient required by the body. The body does make some choline, but it does not make enough to support health and the rest must be acquired through diet. Eggs, and especially egg yolks, are a major dietary source of choline. Choline can also be given as a dietary supplement. Ingestion of choline supplements has been linked to an increased concentration of a compound called TMAO (trimethylamine N-oxide). Elevated TMAO levels have been linked to higher heart disease risk. With this study, the investigators hope to learn whether there is a difference in the way your body responds to the ingestion of a choline supplement versus the choline found within eggs.
Primary Outcome
Changes in levels of non-labeled TMAO from baseline to end-of-study (day 28) as measured by established techniques by mass spectrometry.
Interventions
- DIETARY_SUPPLEMENT Choline Bitartrate
- OTHER Pre-cooked, pre-peeled whole hardboiled eggs
- OTHER Egg whites from pre-cooked, pre-peeled hardboiled eggs
- DIETARY_SUPPLEMENT Phosphatidylcholine capsules
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 86 participants |
| Start Date | 2016-09-02 |
| Est. Completion | 2020-09-03 |
| Phase | NA |
What the finished NCT03039023 record still lists
NCT03039023 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 86 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 4 interventions - of which Choline Bitartrate is the first listed.
NCT03039023 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03039023 about?
NCT03039023 is a clinical study titled "Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans". The investigators are interested in learning more about choline, a nutrient required by the body. The body does make some choline, but it does not make enough to support health and the rest must be acquired through diet. Eggs, and especially egg yolks, are a major dietary source of choline. Choline ...
What is the current status of trial NCT03039023?
This trial is currently completed. It is a NA study. The enrollment target is 86 participants. The study started on 2016-09-02. Estimated completion is 2020-09-03.
What interventions are being tested in trial NCT03039023?
The interventions under investigation include: Choline Bitartrate (DIETARY_SUPPLEMENT), Pre-cooked, pre-peeled whole hardboiled eggs (OTHER), Egg whites from pre-cooked, pre-peeled hardboiled eggs (OTHER), Phosphatidylcholine capsules (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT03039023?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03039023's enrollment target sits among peer trials
86 976th of 2000 higher than 1,021 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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