Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT03037879 · ClinicalTrials.gov registry record · NA

Treating Cognitive Deficits in Spinal Cord Injury

A NA study of Blood Pressure and Spinal Cord Injury, sponsored by James J. Peters Veterans Affairs Medical Center.

Completed
Registry status
NA
Development phase
10
Enrollment target
1
Study location

NCT03037879: Completed NA study of Blood Pressure and Spinal Cord Injury, sponsored by James J. Peters Veterans Affairs Medical Center.

NCT03037879 is a NA study of Blood Pressure and Spinal Cord Injury that has completed, run by James J. Peters Veterans Affairs Medical Center. The registered enrollment target is 10 participants, below the 287-participant average among 101 other Blood Pressure trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT03037879, a NA study of Blood Pressure and Spinal Cord Injury, has completed, sponsored by James J. Peters Veterans Affairs Medical Center.

COMPLETED
Registry status
NA
Development phase
10 participants
Enrollment target
1
Study location

Study Summary

Multiple studies in the spinal cord injury (SCI) population have documented deficits in learning and memory (LM) and processing speed (PS) that adversely impact daily life and the ability to benefit from rehabilitation. The investigators have previously attributed the cognitive deficits demonstrated in the SCI population to low blood pressure (BP) and cerebral blood flow (CBF) and are currently conducting a study to determine the effect of a 30-day elevation in BP (using midodrine hydrochloride - an alpha agonist) on CBF and cognitive performance compared to placebo in hypotensive individuals with SCI. In addition, the investigators believe that cognitive behavior therapy (CBT) may improve cognition independent of changes in BP and CBF in individuals with SCI. The current randomized clinical trial (RCT) will examine the efficacy of 2 treatment protocols shown to be effective in improving cognitive performance in other neurologically impaired populations for use in persons with SCI demonstrating (1) LM impairment and/or (2) PS impairment on objective measures of cognitive functioning during a complete Neuropsychological assessment. Two methods of outcome assessment will be used to examine treatment impact: (1) a traditional Neuropsychological assessment (NP) and (2) an assessment of global functioning (AGF) composed of broader outcome measures that examine the impact of the treatment on everyday life activities. In this way, the investigators will be able to objectively evaluate the presence or absence of changes in memory performance through a NP assessment, while also evaluating the impact of this treatment protocol on everyday life through the AGF. While most studies evaluating the efficacy of cognitive retraining usually employ a pre- and post-training evaluation, such evaluations have been criticized for their lack of ecological validity (i.e., real world generalizability). The present design allows the assessment of the efficacy of these treatment techniques wi

Primary Outcome

NP testing will be conducted to document levels of cognitive performance. NP assessment will identify persons who qualifies for study participation.

Conditions Studied

Blood Pressure Spinal Cord Injury Cognitive Function Cerebral Blood Flow

Interventions

  • OTHER SPT
  • OTHER SPT Control
  • OTHER mSMT
  • OTHER mSMT Control

Study Locations (1)

New Jersey

  • Kessler Foundation - West Orange

Trial Details

FieldValue
Enrollment Target 10 participants
Start Date 2017-04-13
Est. Completion 2021-09-30
Phase NA
James J. Peters Veterans Affairs Medical Center

39 total trials

What the finished NCT03037879 record still lists

NCT03037879 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 287-participant average among 101 other Blood Pressure trials with a reported enrollment target (97% lower).

The record links to 4 conditions, with Blood Pressure appearing as the primary indexed condition, and to 4 interventions - of which SPT is the first listed.

NCT03037879 reports a single indexed study location in New Jersey.

Frequently Asked Questions

What is clinical trial NCT03037879 about?

NCT03037879 is a clinical study titled "Treating Cognitive Deficits in Spinal Cord Injury". Multiple studies in the spinal cord injury (SCI) population have documented deficits in learning and memory (LM) and processing speed (PS) that adversely impact daily life and the ability to benefit from rehabilitation. The investigators have previously attributed the cognitive deficits demonstrated...

What is the current status of trial NCT03037879?

This trial is currently completed. It is a NA study. The enrollment target is 10 participants. The study started on 2017-04-13. Estimated completion is 2021-09-30.

What conditions does trial NCT03037879 study?

This clinical trial studies the following conditions: Blood Pressure, Spinal Cord Injury, Cognitive Function, Cerebral Blood Flow.

What interventions are being tested in trial NCT03037879?

The interventions under investigation include: SPT (OTHER), SPT Control (OTHER), mSMT (OTHER), mSMT Control (OTHER).

Who is sponsoring clinical trial NCT03037879?

This trial is sponsored by James J. Peters Veterans Affairs Medical Center, which has 39 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT03037879 being conducted?

This trial has 1 study location across New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Blood Pressure

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT03037879's enrollment target sits among peer trials

10 97th of 101 higher than 3 of 101 other Blood Pressure trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Blood Pressure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT00623389 · 10 participants · NA

    Evaluation of an Advanced Lower Extremity Neuroprostheses

  • NCT01241864 · 10 participants · Phase 2

    Islet Transplantation in Type 1 Diabetic Kidney Allograft

  • NCT01293214 · 10 participants · NA

    Vascularized Composite Allotransplantation for Multiple Extremity Amputations

  • NCT01474148 · 10 participants · NA

    A Neuroprosthesis for Seated Posture and Balance

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

Related registry views

Source: ClinicalTrials.gov NCT03037879, the US trial registry maintained by the National Library of Medicine. NCT03037879 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.