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NCT04884802 · ClinicalTrials.gov registry record · NA
The GUARDIAN Trial
A NA study of Blood Pressure, sponsored by The University of Texas Health Science Center, Houston.
- Recruiting
- Registry status
- NA
- Development phase
- 6,254
- Enrollment target
- 20
- Study locations
NCT04884802: Recruiting NA study of Blood Pressure, sponsored by The University of Texas Health Science Center, Houston.
NCT04884802 is a NA study of Blood Pressure that is actively recruiting participants, run by The University of Texas Health Science Center, Houston. The registered enrollment target is 6,254 participants, above the 225-participant average among 101 other Blood Pressure trials with a reported enrollment target (2680% higher). The trial reports 20 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04884802, a NA study of Blood Pressure, is actively recruiting participants, sponsored by The University of Texas Health Science Center, Houston.
- RECRUITING
- Registry status
- NA
- Development phase
- 6,254 participants
- Enrollment target
- 20
- Study locations
Study Summary
An international randomized trial to test the primary hypothesis that perioperative tight blood pressure management reduces a composite of major perfusion-related complications (myocardial injury, stroke, non-fatal cardiac arrest, Stage 2-3 acute kidney injury, deep or organ-space infection, sepsis, and death) in the 30 days after major non-cardiac surgery. The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management (routine pressure management).
Primary Outcome
The primary outcome is a composite of major perfusion-related complications (myocardial injury, stroke, non-fatal cardiac arrest, Stage 2-3 acute kidney injury, deep or organ-space infection, sepsis, and death) in the 30 days after major non-cardiac surgery.
Conditions Studied
Interventions
- PROCEDURE Tight blood pressure management
- PROCEDURE Routine blood pressure management
Study Locations (20)
Other
- Beijing Shijitan Hospital, Capital Medical University - Beijing
- Peking Union Medical College Hospital - Beijing
- Peking University First Hospital - Beijing
- West China University Hospital - Chengdu
- Prince of Wales Hospital, Chinese University of Hong Kong, Shatin - Hong Kong
- Renji Hospital, Shanghai Jiaotong University School of Medicine - Shanghai
- Shanghai Chest Hospital - Shanghai
- Shanghai Ninth People's Hospital - Shanghai
- The Affiliated Lianyungang Hospital of Xuzhou Medical University - Xuzhou
- University of Thessaly - Larissa
- IRCCS Regina Elena National Cancer Institute - Rome
- National Defense Medical College - Tokyo
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital - Bakırköy
- Konya City Hospital - Konya
Ohio
- MetroHealth Medical Center - Cleveland
- Cleveland Clinic Fairview Hospital - Cleveland
- Cleveland Clinic Main Campus - Cleveland
Nebraska
- University of Nebraska Medical Center - Omaha
North Carolina
- Wake Forest University - Wake Forest
Texas
- The University of Texas Health Science Center at Houston - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6,254 participants |
| Start Date | 2021-07-25 |
| Est. Completion | 2027-04-25 |
| Phase | NA |
What NCT04884802 shows while recruiting
NCT04884802 is an interventional study that assigns participants to a tested intervention. Its 6,254 participants enrollment target places it among the larger protocols in the corpus, above the 225-participant average among 101 other Blood Pressure trials with a reported enrollment target (2680% higher).
The record links to 1 condition, with Blood Pressure appearing as the primary indexed condition, and to 2 interventions - of which Tight blood pressure management is the first listed.
NCT04884802 names 20 study sites across 5 states, led by Other, Ohio, Nebraska.
Frequently Asked Questions
What is clinical trial NCT04884802 about?
NCT04884802 is a clinical study titled "The GUARDIAN Trial". An international randomized trial to test the primary hypothesis that perioperative tight blood pressure management reduces a composite of major perfusion-related complications (myocardial injury, stroke, non-fatal cardiac arrest, Stage 2-3 acute kidney injury, deep or organ-space infection, sepsis,...
What is the current status of trial NCT04884802?
This trial is currently recruiting. It is a NA study. The enrollment target is 6,254 participants. The study started on 2021-07-25. Estimated completion is 2027-04-25.
What conditions does trial NCT04884802 study?
This clinical trial studies the following conditions: Blood Pressure.
What interventions are being tested in trial NCT04884802?
The interventions under investigation include: Tight blood pressure management (PROCEDURE), Routine blood pressure management (PROCEDURE).
Who is sponsoring clinical trial NCT04884802?
This trial is sponsored by The University of Texas Health Science Center, Houston, which has 732 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04884802 being conducted?
This trial has 20 study locations across Nebraska, North Carolina, Ohio, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Blood Pressure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04884802's enrollment target sits among peer trials
6,254 1st of 101 higher than 101 of 101 other Blood Pressure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Blood Pressure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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