Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Optimizing Outcomes of Treatment-Resistant Depression in Older Adults
NCT02960763 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this research study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD).
Conditions Studied
Interventions
- DRUG Aripiprazole Augmentation
- DRUG Bupropion Augmentation
- DRUG Switch to bupropion
- DRUG Lithium Augmentation
- DRUG Switch to nortriptyline
Study Locations (5)
California
- UCLA Late-Life Mood, Stress, and Wellness Research Program — Los Angeles
Missouri
- Washington University School of Medicine Healthy Mind Lab — St Louis
New York
- Columbia University Adult and Late Life Depression Clinic — New York
Pennsylvania
- UPMC Late-Life Depression, Evaluation, Prevention, and Treatment Program — Pittsburgh
Ontario
- Centre for Addiction and Mental Health — Toronto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 742 participants |
| Start Date | 2017-02-24 |
| Est. Completion | 2021-09-01 |
| Phase | Phase 4 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02960763
The ClinicalTrials.gov registry entry for NCT02960763 describes a study currently listed as completed. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 742 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Washington University School of Medicine, which has 1,036 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 5 interventions — of which Aripiprazole Augmentation is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02960763 reports 5 study locations spanning 5 distinct geographic areas — top geographies include California, Missouri, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02960763 about?
NCT02960763 is a clinical study titled "Optimizing Outcomes of Treatment-Resistant Depression in Older Adults". The purpose of this research study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD).
What is the current status of trial NCT02960763?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 742 participants. The study started on 2017-02-24. Estimated completion is 2021-09-01.
What conditions does trial NCT02960763 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Treatment Resistant Depression, Late Life Depression, Treatment-Refractory Depression, Geriatric Depression. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02960763?
The interventions under investigation include: Aripiprazole Augmentation (DRUG), Bupropion Augmentation (DRUG), Switch to bupropion (DRUG), Lithium Augmentation (DRUG), Switch to nortriptyline (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02960763?
This trial is sponsored by Washington University School of Medicine, which has 1,036 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02960763 being conducted?
This trial has 5 study locations across California, Missouri, New York, Pennsylvania, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.