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COMPLETED Phase 3

rVWF IN PROPHYLAXIS

NCT02973087 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this phase 3 study is to investigate the efficacy and safety, including immunogenicity, thrombogenicity and hypersensitivity reactions, as well as pharmacokinetics (PK), health related quality of life (HRQoL) and pharmacoeconomics of prophylactic treatment with recombinant von Willebrand factor (rVWF) (vonicog alfa) in adult participants with severe von Willebrand disease (VWD).

Conditions Studied

Interventions

  • BIOLOGICAL Antihemophilic Factor (Recombinant)
  • BIOLOGICAL von Willebrand factor (Recombinant)

Study Locations (20)

Other

  • Hamilton Health Sciences Centre — Hamilton
  • Groupement Hospitalier Est- Hôpital Louis Pradel — Bron
  • CHU CAEN - Hôpital de la Côte de Nacre — Caen
  • CHU Dijon - Hopital du Bocage — Dijon
  • Hopital Cardiologique - CHU Lille — Lille
  • Coagulation Research Centre GmbH — Duisburg
  • Klinikum der Johann Wolfgang Goethe-Universitaet — Frankfurt
  • Werlhof-Institut GmbH — Hanover
  • Medizinische Hochschule Hannover — Hanover
  • Azienda Ospedaliera Universitaria Careggi — Florence
  • Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico — Milan

Florida

  • University of Florida College of Medicine — Gainesville
  • University of Florida College of Medicine — Jacksonville

Indiana

  • University of Colorado Health — Aurora
  • Indiana Hemophilia and Thrombosis Center — Indianapolis

Colorado

  • University of Colorado Health — Loveland

Illinois

  • Bleeding and Clotting Disorders Institute — Peoria

Michigan

  • Henry Ford Hospital — Detroit

North Carolina

  • Comprehensive Cancer Center of Wake Forest Unversity — Winston-Salem

Finistere

  • Hôpital Morvan — Brest

Trial Details

FieldValue
Enrollment Target 29 participants
Start Date 2017-11-16
Est. Completion 2020-07-06
Phase Phase 3

Sponsor

Takeda

387 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02973087

The ClinicalTrials.gov registry entry for NCT02973087 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 29 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Takeda, which has 387 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Von Willebrand Disease appearing as the primary indexed condition, and to 2 interventions — of which Antihemophilic Factor (Recombinant) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02973087 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, Florida, Indiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02973087 about?

NCT02973087 is a clinical study titled "rVWF IN PROPHYLAXIS". The purpose of this phase 3 study is to investigate the efficacy and safety, including immunogenicity, thrombogenicity and hypersensitivity reactions, as well as pharmacokinetics (PK), health related quality of life (HRQoL) and pharmacoeconomics of prophylactic treatment with recombinant von Willebr...

What is the current status of trial NCT02973087?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 29 participants. The study started on 2017-11-16. Estimated completion is 2020-07-06.

What conditions does trial NCT02973087 study?

This clinical trial studies the following conditions: Von Willebrand Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02973087?

The interventions under investigation include: Antihemophilic Factor (Recombinant) (BIOLOGICAL), von Willebrand factor (Recombinant) (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02973087?

This trial is sponsored by Takeda, which has 387 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02973087 being conducted?

This trial has 20 study locations across Colorado, Florida, Illinois, Indiana, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial