Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT02917993 · ClinicalTrials.gov registry record · Phase 1

An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung Cancer

A Phase 1 study, sponsored by Incyte Corporation.

Completed
Registry status
Phase 1
Development phase
59
Enrollment target

NCT02917993: Completed Phase 1 study, sponsored by Incyte Corporation.

NCT02917993 is a Phase 1 study that has completed, run by Incyte Corporation. The registered enrollment target is 59 participants, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT02917993, a Phase 1 study, has completed, sponsored by Incyte Corporation.

COMPLETED
Registry status
Phase 1
Development phase
59 participants
Enrollment target

Study Summary

The purpose of this study is to evaluate the safety and tolerability of itacitinib in combination with osimertinib in subjects with locally advanced or metastatic non-small cell lung cancer (NSCLC).

Interventions

  • DRUG Osimertinib
  • DRUG Itacitinib

Trial Details

FieldValue
Enrollment Target 59 participants
Start Date 2016-12-20
Est. Completion 2025-12-24
Phase Phase 1
Incyte Corporation

239 total trials

What the finished NCT02917993 record still lists

NCT02917993 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 59 participants, a relatively small participant target, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target.

The record links to 0 conditions, and to 2 interventions - of which Osimertinib is the first listed.

NCT02917993 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT02917993 about?

NCT02917993 is a clinical study titled "An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung Cancer". The purpose of this study is to evaluate the safety and tolerability of itacitinib in combination with osimertinib in subjects with locally advanced or metastatic non-small cell lung cancer (NSCLC).

What is the current status of trial NCT02917993?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 59 participants. The study started on 2016-12-20. Estimated completion is 2025-12-24.

What interventions are being tested in trial NCT02917993?

The interventions under investigation include: Osimertinib (DRUG), Itacitinib (DRUG).

Who is sponsoring clinical trial NCT02917993?

This trial is sponsored by Incyte Corporation, which has 239 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT02917993's enrollment target sits among peer trials

59 895th of 2000 higher than 1,106 of 2,000 other Phase 1 trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT03801083 · 59 participants · Phase 2

    Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers

  • NCT04332367 · 59 participants · Phase 2

    Carboplatin, Taxane And Ramucirumab for Patients With NSCLC After Pemetrexed or Pembrolizumab Maintenance

  • NCT05489575 · 59 participants · NA

    CPAP for the Treatment of Supine Hypertension

  • NCT06721689 · 59 participants · Phase 1

    PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

Source: ClinicalTrials.gov NCT02917993, the US trial registry maintained by the National Library of Medicine. NCT02917993 (small enrollment · none site footprint · completed) retrieved and formatted by PlainTrial, see methodology.