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NCT02815917 · ClinicalTrials.gov registry record · Phase 1
Evaluation of D3 Receptor Occupancy Using FLUORTRIOPRIDE ([18F]FTP) PET/CT
A Phase 1 study of Healthy Volunteer and D3 Dopamine Receptor, sponsored by University of Pennsylvania.
- Active
- Registry status
- Phase 1
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT02815917: Active Phase 1 study of Healthy Volunteer and D3 Dopamine Receptor, sponsored by University of Pennsylvania.
NCT02815917 is a Phase 1 study of Healthy Volunteer and D3 Dopamine Receptor that is active but no longer recruiting, run by University of Pennsylvania. The registered enrollment target is 30 participants, below the 202-participant average among 112 other Healthy Volunteer trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02815917, a Phase 1 study of Healthy Volunteer and D3 Dopamine Receptor, is active but no longer recruiting, sponsored by University of Pennsylvania.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Preclinical work suggests that D3 dopamine receptors may be important in the study of the pathophysiology of affective disorders, psychotic disorders and addiction. D3 receptors may also play a role in dystonia, Parkinson's disease and response to treatment of these disorders. However, there has been a lack of specific radioligands for imaging D3 receptors. This proposed protocol will evaluate the uptake of \[18F\]FTP as a more specific in vivo measure of D3 receptor binding in the brain in healthy volunteers subjects after injection of lorazepam vs placebo, and in cocaine-dependent subjects. Test-retest scans will evaluate the variability of \[18F\]FTP uptake measures in both healthy volunteer subjects and cocaine-dependent subjects.
Conditions Studied
Interventions
- DRUG [18F]FTP PET/CT
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2016-06 |
| Est. Completion | 2026-06 |
| Phase | Phase 1 |
What the registry record for NCT02815917 still lists
NCT02815917 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 202-participant average among 112 other Healthy Volunteer trials with a reported enrollment target (85% lower).
The record links to 3 conditions, with Healthy Volunteer appearing as the primary indexed condition, and to 1 intervention - of which [18F]FTP PET/CT is the first listed.
NCT02815917 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT02815917 about?
NCT02815917 is a clinical study titled "Evaluation of D3 Receptor Occupancy Using FLUORTRIOPRIDE ([18F]FTP) PET/CT". Preclinical work suggests that D3 dopamine receptors may be important in the study of the pathophysiology of affective disorders, psychotic disorders and addiction. D3 receptors may also play a role in dystonia, Parkinson's disease and response to treatment of these disorders. However, there has bee...
What is the current status of trial NCT02815917?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2016-06. Estimated completion is 2026-06.
What conditions does trial NCT02815917 study?
This clinical trial studies the following conditions: Healthy Volunteer, D3 Dopamine Receptor, Cocaine-dependent.
What interventions are being tested in trial NCT02815917?
The interventions under investigation include: [18F]FTP PET/CT (DRUG).
Who is sponsoring clinical trial NCT02815917?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02815917 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT02815917's enrollment target sits among peer trials
30 76th of 112 higher than 35 of 112 other Healthy Volunteer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy Volunteer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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