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NCT02746575 · ClinicalTrials.gov registry record · Phase 4
Pilot - Peri-operative Beta Blockade
A Phase 4 study of Adrenergic Beta-Receptor Blockader and Troponin Levels, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- Phase 4
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT02746575: Completed Phase 4 study of Adrenergic Beta-Receptor Blockader and Troponin Levels, sponsored by Washington University School of Medicine.
NCT02746575 is a Phase 4 study of Adrenergic Beta-Receptor Blockader and Troponin Levels that has completed, run by Washington University School of Medicine. The registered enrollment target is 70 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02746575, a Phase 4 study of Adrenergic Beta-Receptor Blockader and Troponin Levels, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
Perioperative cardiac adverse events \[heart injuries caused by general anesthesia and surgical procedures\] are a significant public health issue, with more than 60,000 deaths per annum in patients having surgery for non-heart related issues. There are virtually no evidence-based medical strategies for effective prevention of these events. Preoperative drug treatment with beta blockade drugs used for high blood pressure, perioperative therapy with lipid lowering drugs such as statins, alpha-receptor agonists such as clonidine used for high blood pressure, and aspirin have all been investigated as potential mitigating treatments, but without positive clinical outcomes and, in some cases, creating more hemodynamic instabilities that result in heart injury. In light of this, investigators propose to evaluate the safety and efficacy of using increasing doses of beta blockade drugs immediately after surgery and to assess the value of high-sensitivity cardiac troponin level testing of the blood in predicting those patients who would benefit most from perioperative beta blocker therapy.
Primary Outcome
Difference in hscTnI concentrations between preoperative clinic visit and day of surgery
Conditions Studied
Interventions
- DRUG metoprolol
Study Locations (1)
Missouri
- Barnes-Jewish Hospital/Washington University in St. Louis School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2015-11 |
| Est. Completion | 2017-10 |
| Phase | Phase 4 |
What the finished NCT02746575 record still lists
NCT02746575 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (86% lower).
The record links to 3 conditions, with Adrenergic Beta-Receptor Blockader appearing as the primary indexed condition, and to 1 intervention - of which metoprolol is the first listed.
NCT02746575 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT02746575 about?
NCT02746575 is a clinical study titled "Pilot - Peri-operative Beta Blockade". Perioperative cardiac adverse events \[heart injuries caused by general anesthesia and surgical procedures\] are a significant public health issue, with more than 60,000 deaths per annum in patients having surgery for non-heart related issues. There are virtually no evidence-based medical strategies...
What is the current status of trial NCT02746575?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 70 participants. The study started on 2015-11. Estimated completion is 2017-10.
What conditions does trial NCT02746575 study?
This clinical trial studies the following conditions: Adrenergic Beta-Receptor Blockader, Troponin Levels, Cardiomyopathy, Post-surgical.
What interventions are being tested in trial NCT02746575?
The interventions under investigation include: metoprolol (DRUG).
Who is sponsoring clinical trial NCT02746575?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02746575 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02746575's enrollment target sits among peer trials
70 1043rd of 2000 higher than 931 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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