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NCT02746575 · ClinicalTrials.gov registry record · Phase 4
Pilot - Peri-operative Beta Blockade
A Phase 4 study of Adrenergic Beta-Receptor Blockader and Troponin Levels, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- Phase 4
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT02746575 is a Phase 4 study of Adrenergic Beta-Receptor Blockader and Troponin Levels that has completed, run by Washington University School of Medicine. The registered enrollment target is 70 participants. The trial reports 1 study location across 1 state.
The verdict
NCT02746575, a Phase 4 study of Adrenergic Beta-Receptor Blockader and Troponin Levels, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
Perioperative cardiac adverse events \[heart injuries caused by general anesthesia and surgical procedures\] are a significant public health issue, with more than 60,000 deaths per annum in patients having surgery for non-heart related issues. There are virtually no evidence-based medical strategies for effective prevention of these events. Preoperative drug treatment with beta blockade drugs used for high blood pressure, perioperative therapy with lipid lowering drugs such as statins, alpha-receptor agonists such as clonidine used for high blood pressure, and aspirin have all been investigated as potential mitigating treatments, but without positive clinical outcomes and, in some cases, creating more hemodynamic instabilities that result in heart injury. In light of this, investigators propose to evaluate the safety and efficacy of using increasing doses of beta blockade drugs immediately after surgery and to assess the value of high-sensitivity cardiac troponin level testing of the blood in predicting those patients who would benefit most from perioperative beta blocker therapy.
Conditions Studied
Interventions
- DRUG metoprolol
Study Locations (1)
Missouri
- Barnes-Jewish Hospital/Washington University in St. Louis School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2015-11 |
| Est. Completion | 2017-10 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02746575
The ClinicalTrials.gov registry entry for NCT02746575 describes a study currently listed as completed, categorized as Phase 4. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Washington University School of Medicine, which has 1,502 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Adrenergic Beta-Receptor Blockader appearing as the primary indexed condition, and to 1 intervention - of which metoprolol is the first listed.
NCT02746575 reports 1 study location spanning 1 distinct geographic area - top geographies include Missouri.
Frequently Asked Questions
What is clinical trial NCT02746575 about?
NCT02746575 is a clinical study titled "Pilot - Peri-operative Beta Blockade". Perioperative cardiac adverse events \[heart injuries caused by general anesthesia and surgical procedures\] are a significant public health issue, with more than 60,000 deaths per annum in patients having surgery for non-heart related issues. There are virtually no evidence-based medical strategies...
What is the current status of trial NCT02746575?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 70 participants. The study started on 2015-11. Estimated completion is 2017-10.
What conditions does trial NCT02746575 study?
This clinical trial studies the following conditions: Adrenergic Beta-Receptor Blockader, Troponin Levels, Cardiomyopathy, Post-surgical.
What interventions are being tested in trial NCT02746575?
The interventions under investigation include: metoprolol (DRUG).
Who is sponsoring clinical trial NCT02746575?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02746575 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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