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NCT02592967 · ClinicalTrials.gov registry record · Phase 1
Safety & Immunogenicity of JNJ-64041757, Live-attenuated Double-deleted Listeria Immunotherapy, in Subjects With Non Small Cell Lung Cancer
A Phase 1 study, sponsored by Janssen Research & Development.
- Terminated
- Registry status
- Phase 1
- Development phase
- 18
- Enrollment target
NCT02592967: Clinical Trial Phase 1 study, sponsored by Janssen Research & Development.
NCT02592967 is a Phase 1 study that was terminated before completion, run by Janssen Research & Development. The registered enrollment target is 18 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (70% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02592967, a Phase 1 study, was terminated before completion, sponsored by Janssen Research & Development.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 18 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the recommended Phase 2 dose (RP2D) of JNJ-64041757 a live attenuated double deleted (LADD) Listeria monocytogenes (bacteria in which two virulence genes, which encode molecules that help cause disease, have been removed) when administered intravenously to participants with advanced (Stage IIIb) or metastatic (Stage IV) NSCLC (adenocarcinoma).
Primary Outcome
Percentage of participants who experienced DLT will be evaluated. The DLT dose level is defined as an unacceptable level of toxicity as evidenced by a DLT rate of greater than or equal to (\>=) 33%.
Interventions
- BIOLOGICAL JNJ-64041757 (Cohort 1A and 1B)
- BIOLOGICAL JNJ-64041757 (Cohort 2A and 2B)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2015-12-02 |
| Est. Completion | 2018-10-22 |
| Phase | Phase 1 |
Why NCT02592967 stopped before completion
NCT02592967 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (70% lower).
The record links to 0 conditions, and to 2 interventions - of which JNJ-64041757 (Cohort 1A and 1B) is the first listed.
NCT02592967 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02592967 about?
NCT02592967 is a clinical study titled "Safety & Immunogenicity of JNJ-64041757, Live-attenuated Double-deleted Listeria Immunotherapy, in Subjects With Non Small Cell Lung Cancer". The purpose of this study is to determine the recommended Phase 2 dose (RP2D) of JNJ-64041757 a live attenuated double deleted (LADD) Listeria monocytogenes (bacteria in which two virulence genes, which encode molecules that help cause disease, have been removed) when administered intravenously to p...
What is the current status of trial NCT02592967?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2015-12-02. Estimated completion is 2018-10-22.
What interventions are being tested in trial NCT02592967?
The interventions under investigation include: JNJ-64041757 (Cohort 1A and 1B) (BIOLOGICAL), JNJ-64041757 (Cohort 2A and 2B) (BIOLOGICAL).
Who is sponsoring clinical trial NCT02592967?
This trial is sponsored by Janssen Research & Development, which has 593 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02592967's enrollment target sits among peer trials
18 1720th of 2000 higher than 216 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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