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NCT02590068 · ClinicalTrials.gov registry record · NA
Effects of Chronic Viral Infection on Immune Response to Zoster Vaccination
A NA study, sponsored by Rockefeller University.
- Terminated
- Registry status
- NA
- Development phase
- 14
- Enrollment target
NCT02590068 is a NA study that was terminated before completion, run by Rockefeller University. The registered enrollment target is 14 participants.
The verdict
NCT02590068, a NA study, was terminated before completion, sponsored by Rockefeller University.
- TERMINATED
- Registry status
- NA
- Development phase
- 14 participants
- Enrollment target
Study Summary
This study aims to identify the innate and adaptive immune response to zoster vaccination. Half of the participants will be individuals with chronic hepatitis C, while the other half with healthy volunteers.The innate immune signature elicited by Zoster vaccination will be characterized by RNA-seq analysis of pre- and post-vaccination RNA from whole blood. We will compare fold changes in gene expression profiles pre- versus post-vaccination in each individual, as well as between the two arms of the study. RNA-seq will be used to assess innate immune activation by evaluating the changes to the expression levels of interferon-stimulated genes pre- and post-vaccination. Adaptive immune response will be determined by the traditional correlates of protection used in previous Zoster clinical studies in addition to flow cytometry24. Correlates of protection include antibody response, interferon gamma production and the frequency of responder cells post- vaccination24. For antibody production, we will perform Zoster glycoprotein ELISA (gpELISA) targeting IgG/IgM. The number and frequency of responder cells will be characterized by flow cytometry.
Interventions
- DRUG Zoster vaccine live
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2015-12 |
| Est. Completion | 2017-09-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02590068
The ClinicalTrials.gov registry entry for NCT02590068 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 14 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Rockefeller University, which has 117 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Zoster vaccine live is the first listed.
NCT02590068 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02590068 about?
NCT02590068 is a clinical study titled "Effects of Chronic Viral Infection on Immune Response to Zoster Vaccination". This study aims to identify the innate and adaptive immune response to zoster vaccination. Half of the participants will be individuals with chronic hepatitis C, while the other half with healthy volunteers.The innate immune signature elicited by Zoster vaccination will be characterized by RNA-seq a...
What is the current status of trial NCT02590068?
This trial is currently terminated. It is a NA study. The enrollment target is 14 participants. The study started on 2015-12. Estimated completion is 2017-09-08.
What interventions are being tested in trial NCT02590068?
The interventions under investigation include: Zoster vaccine live (DRUG).
Who is sponsoring clinical trial NCT02590068?
This trial is sponsored by Rockefeller University, which has 117 total clinical trials registered on ClinicalTrials.gov.
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