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ACTIVE NOT RECRUITING Phase 2

Testing the Combination of Cediranib and Olaparib in Comparison to Each Drug Alone or Other Chemotherapy in Recurrent Platinum-Resistant Ovarian Cancer

NCT02502266 · View on ClinicalTrials.gov ↗

Study Summary

This randomized phase II/III trial studies how well cediranib maleate and olaparib work when given together or separately, and compares them to standard chemotherapy in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that has returned (recurrent) after receiving chemotherapy with drugs that contain platinum (platinum-resistant) or continued to grow while being treated with platinum-based chemotherapy drugs (platinum-refractory). Cediranib maleate and olaparib may stop the growth of tumor cells by blocking enzymes needed for cell growth. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving cediranib maleate and olaparib together may cause more damage to cancer cells when compared to either drug alone or standard chemotherapy.

Interventions

  • PROCEDURE Computed Tomography
  • PROCEDURE Magnetic Resonance Imaging
  • DRUG Olaparib
  • DRUG Cediranib
  • DRUG Cediranib Maleate

Study Locations (20)

California

  • Sutter Auburn Faith Hospital — Auburn
  • Alta Bates Summit Medical Center-Herrick Campus — Berkeley
  • Mercy San Juan Medical Center — Carmichael
  • Mercy Cancer Center - Elk Grove — Elk Grove
  • Marin Cancer Care Inc — Greenbrae
  • UC San Diego Moores Cancer Center — La Jolla
  • Palo Alto Medical Foundation-Camino Division — Mountain View
  • Palo Alto Medical Foundation-Gynecologic Oncology — Mountain View
  • Kaiser Permanente-Oakland — Oakland
  • Palo Alto Medical Foundation Health Care — Palo Alto
  • Mercy Cancer Center - Rocklin — Rocklin
  • Sutter Roseville Medical Center — Roseville
  • Kaiser Permanente Downtown Commons — Sacramento
  • Mercy Cancer Center - Sacramento — Sacramento
  • Sutter Medical Center Sacramento — Sacramento
  • University of California Davis Comprehensive Cancer Center — Sacramento

Alaska

  • Alaska Women's Cancer Care — Anchorage
  • Providence Alaska Medical Center — Anchorage

Alabama

  • University of Alabama at Birmingham Cancer Center — Birmingham

Arkansas

  • University of Arkansas for Medical Sciences — Little Rock

Trial Details

FieldValue
Enrollment Target 582 participants
Start Date 2016-05-03
Est. Completion 2026-12-23
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02502266

The ClinicalTrials.gov registry entry for NCT02502266 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 582 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Ovarian Endometrioid Adenocarcinoma appearing as the primary indexed condition, and to 5 interventions — of which Computed Tomography is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02502266 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Alaska, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02502266 about?

NCT02502266 is a clinical study titled "Testing the Combination of Cediranib and Olaparib in Comparison to Each Drug Alone or Other Chemotherapy in Recurrent Platinum-Resistant Ovarian Cancer". This randomized phase II/III trial studies how well cediranib maleate and olaparib work when given together or separately, and compares them to standard chemotherapy in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that has returned (recurrent) after receiving chemothe...

What is the current status of trial NCT02502266?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 582 participants. The study started on 2016-05-03. Estimated completion is 2026-12-23.

What conditions does trial NCT02502266 study?

This clinical trial studies the following conditions: Ovarian Endometrioid Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Ovarian Serous Adenocarcinoma, Ovarian Clear Cell Adenocarcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02502266?

The interventions under investigation include: Computed Tomography (PROCEDURE), Magnetic Resonance Imaging (PROCEDURE), Olaparib (DRUG), Cediranib (DRUG), Cediranib Maleate (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02502266?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02502266 being conducted?

This trial has 20 study locations across Alabama, Alaska, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial