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ACTIVE NOT RECRUITING Phase 2

Gemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

NCT02101775 · View on ClinicalTrials.gov ↗

Study Summary

This randomized phase II clinical trial studies how well gemcitabine hydrochloride and WEE1 inhibitor MK-1775 work compared to gemcitabine hydrochloride alone in treating patients with ovarian, primary peritoneal, or fallopian tube cancer that has come back after a period of time. Gemcitabine hydrochloride may prevent tumor cells from multiplying by damaging their deoxyribonucleic acid (DNA, molecules that contain instructions for the proper development and functioning of cells), which in turn stops the tumor from growing. The protein WEE1 may help to repair the damaged tumor cells, so the tumor continues to grow. WEE1 inhibitor MK-1775 may block the WEE1 protein activity and may increase the effectiveness of gemcitabine hydrochloride by preventing the WEE1 protein from repairing damaged tumor cells without causing harm to normal cells. It is not yet known whether gemcitabine hydrochloride with or without WEE1 inhibitor MK-1775 may be an effective treatment for recurrent ovarian, primary peritoneal, or fallopian tube cancer.

Interventions

  • OTHER Laboratory Biomarker Analysis
  • DRUG Gemcitabine Hydrochloride
  • OTHER Placebo Administration
  • OTHER Pharmacological Study
  • DRUG Adavosertib

Study Locations (16)

Ontario

  • London Regional Cancer Program — London
  • Ottawa Hospital and Cancer Center-General Campus — Ottawa
  • University Health Network Princess Margaret Cancer Center P2C — Toronto
  • University Health Network-Princess Margaret Hospital — Toronto

California

  • City of Hope Comprehensive Cancer Center — Duarte
  • City of Hope South Pasadena — South Pasadena

Illinois

  • University of Chicago Comprehensive Cancer Center — Chicago
  • Decatur Memorial Hospital — Decatur

Pennsylvania

  • Fox Chase Cancer Center — Philadelphia
  • University of Pittsburgh Cancer Institute (UPCI) — Pittsburgh

British Columbia

  • BCCA-Cancer Centre for the Southern Interior — Kelowna
  • BCCA-Vancouver Cancer Centre — Vancouver

Indiana

  • Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis

Minnesota

  • Mayo Clinic in Rochester — Rochester

Quebec

  • CHUM - Centre Hospitalier de l'Universite de Montreal — Montreal

Trial Details

FieldValue
Enrollment Target 124 participants
Start Date 2014-07-21
Est. Completion 2027-03-06
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02101775

The ClinicalTrials.gov registry entry for NCT02101775 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 124 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Recurrent Fallopian Tube Carcinoma appearing as the primary indexed condition, and to 5 interventions — of which Laboratory Biomarker Analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02101775 reports 16 study locations spanning 9 distinct geographic areas — top geographies include Ontario, California, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02101775 about?

NCT02101775 is a clinical study titled "Gemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer". This randomized phase II clinical trial studies how well gemcitabine hydrochloride and WEE1 inhibitor MK-1775 work compared to gemcitabine hydrochloride alone in treating patients with ovarian, primary peritoneal, or fallopian tube cancer that has come back after a period of time. Gemcitabine hydroc...

What is the current status of trial NCT02101775?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 124 participants. The study started on 2014-07-21. Estimated completion is 2027-03-06.

What conditions does trial NCT02101775 study?

This clinical trial studies the following conditions: Recurrent Fallopian Tube Carcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Seromucinous Carcinoma, Ovarian Brenner Tumor, Ovarian Mucinous Cystadenocarcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02101775?

The interventions under investigation include: Laboratory Biomarker Analysis (OTHER), Gemcitabine Hydrochloride (DRUG), Placebo Administration (OTHER), Pharmacological Study (OTHER), Adavosertib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02101775?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02101775 being conducted?

This trial has 16 study locations across California, Illinois, Indiana, Minnesota, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial