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NCT02437773 · ClinicalTrials.gov registry record · NA
Neurocircuit Mechanisms of OCD Across the Lifespan
A NA study, sponsored by University of Michigan.
- Completed
- Registry status
- NA
- Development phase
- 206
- Enrollment target
NCT02437773: Completed NA study, sponsored by University of Michigan.
NCT02437773 is a NA study that has completed, run by University of Michigan. The registered enrollment target is 206 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02437773, a NA study, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- NA
- Development phase
- 206 participants
- Enrollment target
Study Summary
Obsessive-compulsive disorder (OCD), characterized by intrusive thoughts (obsessions) and related behavioral rituals (compulsions), is a common psychiatric illness that often emerges in childhood and causes life-long disability in over 50% of patients. Psychological theory suggests that OCD symptoms are driven by a person's difficulty disengaging their feelings from simple tasks (e.g. washing hands, locking a door) due to excessive anxiety about performance errors. Cognitive behavioral therapy (CBT), the gold standard treatment for OCD, repeatedly exposes patients to their OCD-stressor until this anxiety is reduced. While CBT is typically more effective in teenagers than adults, patients from both age groups are usually left with residual symptoms, highlighting the need for better treatments. In this study, CBT will be studied in both teen-aged and adult patients. Two groups, both with childhood onset OCD, will be randomized to either CBT for OCD or stress management training (SMT), an active therapy but with minimal effects on OCD symptoms. The investigators will also study age-matched, healthy controls as comparison subjects. Before and after 12 weeks of CBT, all subjects will undergo functional Magnetic Resonance Imaging (fMRI) scans to see what regions of the brain become active when a concentration task is performed and how that activation is changed after CBT. The purpose of this study is to demonstrate the brain changes associated with CBT treatment and how differences in these changes in teenage compared to adult patients may drive differences in CBT response.
Primary Outcome
fMRI BOLD signal response of posterior medial frontal cortex (pMFC), ventral medial prefrontal cortex (vmPFC) and anterior insula (aIns) during performance monitoring. This signal will be measured as BOLD contrast estimates for errors compared to correct trials based on average signal in a priori defined regions of interest for pMFC, vmPFC and aIns. The investigators are looking for increases in pMFC activation in adolescents from pre- to post-treatment. In contrast, the investigators are lookin
Interventions
- BEHAVIORAL Cognitive Behavioral Therapy - Adolescents
- BEHAVIORAL Stress Management Therapy - Adolescents
- BEHAVIORAL Optional CBT - Adolescents
- BEHAVIORAL Cognitive Behavioral Therapy - Adults
- BEHAVIORAL Stress Management Therapy - Adults
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 206 participants |
| Start Date | 2015-03-09 |
| Est. Completion | 2020-10-21 |
| Phase | NA |
What the finished NCT02437773 record still lists
NCT02437773 is an interventional study that assigns participants to a tested intervention. The registered 206 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 5 interventions - of which Cognitive Behavioral Therapy - Adolescents is the first listed.
NCT02437773 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02437773 about?
NCT02437773 is a clinical study titled "Neurocircuit Mechanisms of OCD Across the Lifespan". Obsessive-compulsive disorder (OCD), characterized by intrusive thoughts (obsessions) and related behavioral rituals (compulsions), is a common psychiatric illness that often emerges in childhood and causes life-long disability in over 50% of patients. Psychological theory suggests that OCD symptoms...
What is the current status of trial NCT02437773?
This trial is currently completed. It is a NA study. The enrollment target is 206 participants. The study started on 2015-03-09. Estimated completion is 2020-10-21.
What interventions are being tested in trial NCT02437773?
The interventions under investigation include: Cognitive Behavioral Therapy - Adolescents (BEHAVIORAL), Stress Management Therapy - Adolescents (BEHAVIORAL), Optional CBT - Adolescents (BEHAVIORAL), Cognitive Behavioral Therapy - Adults (BEHAVIORAL), Stress Management Therapy - Adults (BEHAVIORAL).
Who is sponsoring clinical trial NCT02437773?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02437773's enrollment target sits among peer trials
206 499th of 2000 higher than 1,502 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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