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NCT02437773 · ClinicalTrials.gov registry record · NA
Neurocircuit Mechanisms of OCD Across the Lifespan
A NA study, sponsored by University of Michigan.
- Completed
- Registry status
- NA
- Development phase
- 206
- Enrollment target
NCT02437773 is a NA study that has completed, run by University of Michigan. The registered enrollment target is 206 participants.
The verdict
NCT02437773, a NA study, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- NA
- Development phase
- 206 participants
- Enrollment target
Study Summary
Obsessive-compulsive disorder (OCD), characterized by intrusive thoughts (obsessions) and related behavioral rituals (compulsions), is a common psychiatric illness that often emerges in childhood and causes life-long disability in over 50% of patients. Psychological theory suggests that OCD symptoms are driven by a person's difficulty disengaging their feelings from simple tasks (e.g. washing hands, locking a door) due to excessive anxiety about performance errors. Cognitive behavioral therapy (CBT), the gold standard treatment for OCD, repeatedly exposes patients to their OCD-stressor until this anxiety is reduced. While CBT is typically more effective in teenagers than adults, patients from both age groups are usually left with residual symptoms, highlighting the need for better treatments. In this study, CBT will be studied in both teen-aged and adult patients. Two groups, both with childhood onset OCD, will be randomized to either CBT for OCD or stress management training (SMT), an active therapy but with minimal effects on OCD symptoms. The investigators will also study age-matched, healthy controls as comparison subjects. Before and after 12 weeks of CBT, all subjects will undergo functional Magnetic Resonance Imaging (fMRI) scans to see what regions of the brain become active when a concentration task is performed and how that activation is changed after CBT. The purpose of this study is to demonstrate the brain changes associated with CBT treatment and how differences in these changes in teenage compared to adult patients may drive differences in CBT response.
Interventions
- BEHAVIORAL Cognitive Behavioral Therapy - Adolescents
- BEHAVIORAL Stress Management Therapy - Adolescents
- BEHAVIORAL Optional CBT - Adolescents
- BEHAVIORAL Cognitive Behavioral Therapy - Adults
- BEHAVIORAL Stress Management Therapy - Adults
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 206 participants |
| Start Date | 2015-03-09 |
| Est. Completion | 2020-10-21 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02437773
The ClinicalTrials.gov registry entry for NCT02437773 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 206 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Michigan, which has 1,327 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Cognitive Behavioral Therapy - Adolescents is the first listed.
NCT02437773 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02437773 about?
NCT02437773 is a clinical study titled "Neurocircuit Mechanisms of OCD Across the Lifespan". Obsessive-compulsive disorder (OCD), characterized by intrusive thoughts (obsessions) and related behavioral rituals (compulsions), is a common psychiatric illness that often emerges in childhood and causes life-long disability in over 50% of patients. Psychological theory suggests that OCD symptoms...
What is the current status of trial NCT02437773?
This trial is currently completed. It is a NA study. The enrollment target is 206 participants. The study started on 2015-03-09. Estimated completion is 2020-10-21.
What interventions are being tested in trial NCT02437773?
The interventions under investigation include: Cognitive Behavioral Therapy - Adolescents (BEHAVIORAL), Stress Management Therapy - Adolescents (BEHAVIORAL), Optional CBT - Adolescents (BEHAVIORAL), Cognitive Behavioral Therapy - Adults (BEHAVIORAL), Stress Management Therapy - Adults (BEHAVIORAL).
Who is sponsoring clinical trial NCT02437773?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
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