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NCT02428478 · ClinicalTrials.gov registry record · Phase 2
Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study A
A Phase 2 study, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- Phase 2
- Development phase
- 17
- Enrollment target
NCT02428478 is a Phase 2 study that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 17 participants.
The verdict
NCT02428478, a Phase 2 study, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 17 participants
- Enrollment target
Study Summary
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal participants. Until recently, the search for medicines to activate pharyngeal muscles in sleeping humans has been discouraging. However, exciting new animal research has shown that drugs with noradrenergic and antimuscarinic effects can restore pharyngeal muscle activity to waking levels. In this protocol the investigators will test the effect of desipramine (a tricyclic antidepressant with strong noradrenergic and antimuscarinic effects) on genioglossus muscle activity (EMG GG) during sleep in healthy control participants.
Interventions
- DRUG Placebo
- DRUG Desipramine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2015-03 |
| Est. Completion | 2016-03 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02428478
The ClinicalTrials.gov registry entry for NCT02428478 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 17 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT02428478 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02428478 about?
NCT02428478 is a clinical study titled "Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study A". Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal participants. U...
What is the current status of trial NCT02428478?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 17 participants. The study started on 2015-03. Estimated completion is 2016-03.
What interventions are being tested in trial NCT02428478?
The interventions under investigation include: Placebo (DRUG), Desipramine (DRUG).
Who is sponsoring clinical trial NCT02428478?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
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