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COMPLETED Phase 2

Pazopanib Hydrochloride and Topotecan Hydrochloride in Treating Patients With Metastatic Soft Tissue and Bone Sarcomas

NCT02357810 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this clinical research study is to learn if pazopanib when given in combination with topotecan can help to control sarcomas. The safety of this drug combination will also be studied. Pazopanib hydrochloride and topotecan hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Interventions

  • OTHER Laboratory Biomarker Analysis
  • DRUG Pazopanib Hydrochloride
  • DRUG Oral Topotecan Hydrochloride

Study Locations (8)

Illinois

  • Northwestern University — Chicago
  • Northwestern University- Lake Forest Hospital — Lake Forest

Minnesota

  • Masonic Cancer Center, University of Minnesota — Minneapolis
  • Mayo Clinic — Rochester

Arizona

  • Mayo Clinic in Arizona — Scottsdale

Florida

  • Mayo Clinic in Florida — Jacksonville

Iowa

  • University of Iowa Hospitals and Clinics — Iowa City

Missouri

  • Washington University School of Medicine — St Louis

Trial Details

FieldValue
Enrollment Target 178 participants
Start Date 2015-03-21
Est. Completion 2021-10-12
Phase Phase 2

Sponsor

Northwestern University

1,033 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02357810

The ClinicalTrials.gov registry entry for NCT02357810 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 178 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Northwestern University, which has 1,033 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 7 conditions, with Recurrent Osteosarcoma appearing as the primary indexed condition, and to 3 interventions — of which Laboratory Biomarker Analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02357810 reports 8 study locations spanning 6 distinct geographic areas — top geographies include Illinois, Minnesota, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02357810 about?

NCT02357810 is a clinical study titled "Pazopanib Hydrochloride and Topotecan Hydrochloride in Treating Patients With Metastatic Soft Tissue and Bone Sarcomas". The purpose of this clinical research study is to learn if pazopanib when given in combination with topotecan can help to control sarcomas. The safety of this drug combination will also be studied. Pazopanib hydrochloride and topotecan hydrochloride may stop the growth of tumor cells by blocking som...

What is the current status of trial NCT02357810?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 178 participants. The study started on 2015-03-21. Estimated completion is 2021-10-12.

What conditions does trial NCT02357810 study?

This clinical trial studies the following conditions: Recurrent Osteosarcoma, Recurrent Adult Soft Tissue Sarcoma, Metastatic Osteosarcoma, Stage IV Adult Soft Tissue Sarcoma, Recurrent Liposarcoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02357810?

The interventions under investigation include: Laboratory Biomarker Analysis (OTHER), Pazopanib Hydrochloride (DRUG), Oral Topotecan Hydrochloride (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02357810?

This trial is sponsored by Northwestern University, which has 1,033 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02357810 being conducted?

This trial has 8 study locations across Arizona, Florida, Illinois, Iowa, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial