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NCT02297724 · ClinicalTrials.gov registry record
MRI Assessment of Placental Health
A clinical trial of Intrauterine Growth Restriction, sponsored by Boston Children's Hospital.
- Recruiting
- Registry status
- 80
- Enrollment target
- 2
- Study locations
NCT02297724 is a study of Intrauterine Growth Restriction that is actively recruiting participants, run by Boston Children's Hospital. The registered enrollment target is 80 participants. The trial reports 2 study locations across 2 states.
The verdict
NCT02297724, a study of Intrauterine Growth Restriction, is actively recruiting participants, sponsored by Boston Children's Hospital.
- RECRUITING
- Registry status
- 80 participants
- Enrollment target
- 2
- Study locations
Study Summary
The ultimate goal of this project is to develop methods that allow informed decision-making on the delivery time of fetuses that are at increased risk of stillbirth due to IUGR. In placenta related IUGR pregnancies, there can be multiple concurrent placental pathologies. Although there is no specific correspondence between a single type of pathology and IUGR, the common result of these pathologies is placental insufficiency, which limits the maternal-fetal exchange. Oxygen and nutrition transport is known to be hindered in IUGR placentas due to obstructed or abrupt vasculature, massive fibrin deposition, and inflammation in the villous and intervillous space (villitis). Thus one potential approach to distinguish IUGR pregnancies from normal ones is to assess the efficiency of placental transport. Based on the hypothesis that efficiency of oxygen transport is representative for overall oxygen and nutrition transport in placenta, the investigators propose to characterize the blood oxygenation and blood perfusion in placenta in vivo via MRI, and use it as an index for better stratification in the IUGR risk group. The investigators will also consider alternative MRI approaches such as structural, diffusion and spectroscopy measurements inside the placenta, which might reflect the state of placental transport and reveal the status of placental health. Specific aims: 1) To correlate the MRI metrics that differentiate placental insufficiency from normal placenta transport with histopathology data of the placenta. 2) To correlate the MRI metrics that reflects placental insufficiency with fetal outcome
Conditions Studied
Interventions
- OTHER Oxygen
Study Locations (2)
Massachusetts
- Boston Children's Hospital - Boston
Other
- Hospital Universitario de Fuenlabrada - Madrid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2014-04 |
| Est. Completion | 2028-09 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02297724
The ClinicalTrials.gov registry entry for NCT02297724 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Boston Children's Hospital, which has 462 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Intrauterine Growth Restriction appearing as the primary indexed condition, and to 1 intervention - of which Oxygen is the first listed.
NCT02297724 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Massachusetts, Other.
Frequently Asked Questions
What is clinical trial NCT02297724 about?
NCT02297724 is a clinical study titled "MRI Assessment of Placental Health". The ultimate goal of this project is to develop methods that allow informed decision-making on the delivery time of fetuses that are at increased risk of stillbirth due to IUGR. In placenta related IUGR pregnancies, there can be multiple concurrent placental pathologies. Although there is no specifi...
What is the current status of trial NCT02297724?
This trial is currently recruiting. The enrollment target is 80 participants. The study started on 2014-04. Estimated completion is 2028-09.
What conditions does trial NCT02297724 study?
This clinical trial studies the following conditions: Intrauterine Growth Restriction.
What interventions are being tested in trial NCT02297724?
The interventions under investigation include: Oxygen (OTHER).
Who is sponsoring clinical trial NCT02297724?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02297724 being conducted?
This trial has 2 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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