Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 2

Everolimus and Letrozole or Hormonal Therapy to Treat Endometrial Cancer

NCT02228681 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to evaluate the effectiveness of the combination of the drugs Everolimus and Letrozole compared to Tamoxifen and Medroxyprogesterone acetate in treating endometrial cancer and to determine the types and severity of side effects caused by treatment with these drug combinations.

Interventions

  • DRUG Tamoxifen
  • DRUG Letrozole
  • DRUG Everolimus
  • DRUG Medroxyprogesterone Acetate

Study Locations (20)

Georgia

  • John B. Amos Cancer Center — Columbus
  • Memorial Health University Medical Center — Savannah

Mississippi

  • St. Dominic-Jackson Memorial Hospital — Jackson
  • University of Mississippi Medical Center — Jackson

New Mexico

  • New Mexico Cancer Alliance — Albuquerque
  • Memorial Medical Center-Cancer Center — Albuquerque

New York

  • Women's Cancer Care Associates — Albany
  • SUNY Downstate Medical Center — Brooklyn

Ohio

  • University Hospital Case Medical Center — Cleveland
  • Ohio State University — Columbus

Colorado

  • University of Colorado - Anschutz Cancer Pavilion — Aurora

Florida

  • University of Miami - Sylvester Comprehensive Cancer Center — Miami

Maine

  • Maine Medical Center — Scarborough

Trial Details

FieldValue
Enrollment Target 74 participants
Start Date 2015-05-21
Est. Completion 2024-08-22
Phase Phase 2

Sponsor

GOG Foundation

37 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02228681

The ClinicalTrials.gov registry entry for NCT02228681 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 74 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GOG Foundation, which has 37 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced, Persistent, or Recurrent Endometrial Cancer appearing as the primary indexed condition, and to 4 interventions — of which Tamoxifen is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02228681 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Georgia, Mississippi, New Mexico. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02228681 about?

NCT02228681 is a clinical study titled "Everolimus and Letrozole or Hormonal Therapy to Treat Endometrial Cancer". The main purpose of this study is to evaluate the effectiveness of the combination of the drugs Everolimus and Letrozole compared to Tamoxifen and Medroxyprogesterone acetate in treating endometrial cancer and to determine the types and severity of side effects caused by treatment with these drug co...

What is the current status of trial NCT02228681?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 74 participants. The study started on 2015-05-21. Estimated completion is 2024-08-22.

What conditions does trial NCT02228681 study?

This clinical trial studies the following conditions: Advanced, Persistent, or Recurrent Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02228681?

The interventions under investigation include: Tamoxifen (DRUG), Letrozole (DRUG), Everolimus (DRUG), Medroxyprogesterone Acetate (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02228681?

This trial is sponsored by GOG Foundation, which has 37 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02228681 being conducted?

This trial has 20 study locations across Colorado, Florida, Georgia, Maine, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial