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NCT02211755 · ClinicalTrials.gov registry record · Phase 1
Trial of the Combination of Bortezomib and Clofarabine in Adults With Relapsed Solid Tumors
A Phase 1 study, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 1
- Development phase
- 28
- Enrollment target
NCT02211755: Completed Phase 1 study, sponsored by National Cancer Institute (NCI).
NCT02211755 is a Phase 1 study that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 28 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (53% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02211755, a Phase 1 study, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 28 participants
- Enrollment target
Study Summary
Background: \- Researchers want to develop better ways to treat cancer. In this study, they will give people with cancer two drugs. These drugs have been used on their own to treat some blood cell cancers. Objectives: \- To test the safety and efficacy of the drug combination of bortezomib and clofarabine. Eligibility: \- Adults age 18 and over with advanced cancer that has progressed after receiving standard treatment or that has no effective therapy. Design: * Participants will be screened with medical history, physical exam, and scans to measure their tumors. They will also have heart, blood, and urine tests. All of these may be done by their regular doctors. * Participants will get the study drugs in 21-day cyles. They will stay at the clinic for week 1 of every cycle, then have 2 weeks off. \<TAB\>- Bortezomib will be injected under the skin on days 1 and 4. \<TAB\>- Clofarabine will be injected in a vein for days 1-5. * During cycle 1 only, participants will go to the clinic or their doctor to have a physical exam and blood tests at the start of the second and third week. * Participants will have clinical evaluations throughout the study, including before receiving treatment and then before the start of each cycle. * Participants may stay in the study as long as they are tolerating the drugs and their tumor is not getting worse. * Participants will have follow-up for 30 days after the last dose of study drugs. * The first part of this study tests the safety of different doses of clofarabine and bortezomib. * The second part of this study involves a separate group of participants who will undergo mandatory research biopsies to learn more about the effects of clofarabine and bortezomib on cancer cells.
Primary Outcome
To establish the safety, tolerability, and maximum tolerated dose (MTD) of bortezomib and clofarabine in patients with refractory solid tumors or lymphomas or myelodysplastic syndromes
Interventions
- DRUG Bortezomib plus Clofarabine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2014-10-06 |
| Est. Completion | 2025-08-15 |
| Phase | Phase 1 |
What the finished NCT02211755 record still lists
NCT02211755 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 28 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (53% lower).
The record links to 0 conditions, and to 1 intervention - of which Bortezomib plus Clofarabine is the first listed.
NCT02211755 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02211755 about?
NCT02211755 is a clinical study titled "Trial of the Combination of Bortezomib and Clofarabine in Adults With Relapsed Solid Tumors". Background: \- Researchers want to develop better ways to treat cancer. In this study, they will give people with cancer two drugs. These drugs have been used on their own to treat some blood cell cancers. Objectives: \- To test the safety and efficacy of the drug combination of bortezomib and cl...
What is the current status of trial NCT02211755?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 28 participants. The study started on 2014-10-06. Estimated completion is 2025-08-15.
What interventions are being tested in trial NCT02211755?
The interventions under investigation include: Bortezomib plus Clofarabine (DRUG).
Who is sponsoring clinical trial NCT02211755?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02211755's enrollment target sits among peer trials
28 1447th of 2000 higher than 538 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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