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NCT02193724 · ClinicalTrials.gov registry record
Feasibility of Generating Pluripotent Stem Cells From Patients With Familial Retinoblastoma
A clinical trial, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- 15
- Enrollment target
NCT02193724 is a clinical trial that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 15 participants.
The verdict
NCT02193724 has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- 15 participants
- Enrollment target
Study Summary
The goal of this study is to determine if human RB1-deficient induced pluripotent stem cells (iPSCs) can produce retina, and, furthermore, can give rise to retinoblastoma in culture. This unique opportunity to study the initiation of retinoblastoma in the developing retina will shed light on the cell of origin for retinoblastoma and allow the investigators to study the earliest molecular and cellular events in retinoblastoma tumorigenesis. OBJECTIVES: * To establish the feasibility of producing induced pluripotent stem cells (iPSCs) from retinoblastoma patients with germline RB1 mutations (RB1-deficient iPSCs). * To validate human RB1-deficient iPSCs by confirming karyotype, pluripotency and RB1 mutation. * To differentiate the RB1-deficient iPSCs into retina as a model of the initiation of retinoblastoma in the developing retina.
Interventions
- OTHER Blood Draw
- OTHER Skin Biopsy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2014-11-04 |
| Est. Completion | 2019-08-23 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02193724
The ClinicalTrials.gov registry entry for NCT02193724 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Blood Draw is the first listed.
NCT02193724 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02193724 about?
NCT02193724 is a clinical study titled "Feasibility of Generating Pluripotent Stem Cells From Patients With Familial Retinoblastoma". The goal of this study is to determine if human RB1-deficient induced pluripotent stem cells (iPSCs) can produce retina, and, furthermore, can give rise to retinoblastoma in culture. This unique opportunity to study the initiation of retinoblastoma in the developing retina will shed light on the cel...
What is the current status of trial NCT02193724?
This trial is currently completed. The enrollment target is 15 participants. The study started on 2014-11-04. Estimated completion is 2019-08-23.
What interventions are being tested in trial NCT02193724?
The interventions under investigation include: Blood Draw (OTHER), Skin Biopsy (OTHER).
Who is sponsoring clinical trial NCT02193724?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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