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NCT02193724 · ClinicalTrials.gov registry record
Feasibility of Generating Pluripotent Stem Cells From Patients With Familial Retinoblastoma
A clinical trial, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- 15
- Enrollment target
NCT02193724: Completed study, sponsored by St. Jude Children's Research Hospital.
NCT02193724 is a clinical trial that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 15 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02193724 has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- 15 participants
- Enrollment target
Study Summary
The goal of this study is to determine if human RB1-deficient induced pluripotent stem cells (iPSCs) can produce retina, and, furthermore, can give rise to retinoblastoma in culture. This unique opportunity to study the initiation of retinoblastoma in the developing retina will shed light on the cell of origin for retinoblastoma and allow the investigators to study the earliest molecular and cellular events in retinoblastoma tumorigenesis. OBJECTIVES: * To establish the feasibility of producing induced pluripotent stem cells (iPSCs) from retinoblastoma patients with germline RB1 mutations (RB1-deficient iPSCs). * To validate human RB1-deficient iPSCs by confirming karyotype, pluripotency and RB1 mutation. * To differentiate the RB1-deficient iPSCs into retina as a model of the initiation of retinoblastoma in the developing retina.
Primary Outcome
Skin biopsy or peripheral blood mononuclear cells will be collected from eligible, consenting participants and shipped directly to the University of Wisconsin for processing. All samples will be returned to the St. Jude investigator within two months of reprogramming for further analysis.
Interventions
- OTHER Blood Draw
- OTHER Skin Biopsy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2014-11-04 |
| Est. Completion | 2019-08-23 |
What the finished NCT02193724 record still lists
NCT02193724 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 15 participants, a relatively small participant target.
The record links to 0 conditions, and to 2 interventions - of which Blood Draw is the first listed.
NCT02193724 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02193724 about?
NCT02193724 is a clinical study titled "Feasibility of Generating Pluripotent Stem Cells From Patients With Familial Retinoblastoma". The goal of this study is to determine if human RB1-deficient induced pluripotent stem cells (iPSCs) can produce retina, and, furthermore, can give rise to retinoblastoma in culture. This unique opportunity to study the initiation of retinoblastoma in the developing retina will shed light on the cel...
What is the current status of trial NCT02193724?
This trial is currently completed. The enrollment target is 15 participants. The study started on 2014-11-04. Estimated completion is 2019-08-23.
What interventions are being tested in trial NCT02193724?
The interventions under investigation include: Blood Draw (OTHER), Skin Biopsy (OTHER).
Who is sponsoring clinical trial NCT02193724?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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