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NCT02170142 · ClinicalTrials.gov registry record
Characterization of the Functional and Structural Development of the Human Neonatal Brain From 30 Wks to 45 Wks ga
A clinical trial, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- 102
- Enrollment target
NCT02170142: Completed study, sponsored by University of Texas Southwestern Medical Center.
NCT02170142 is a clinical trial that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 102 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02170142 has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- 102 participants
- Enrollment target
Study Summary
The major goal of this project is to characterize the structural and functional development of cortical plate and white matter of the human neonatal brain from the equivalent 30 gestational weeks to 45 gestational weeks. The project is sponsored by niH R01MH092535. Furthermore, it is related to the blue print project of transcriptome atlas (niH RC2MH089921) with at least 36 million funding also sponsored by niH. Revealing detailed anatomy at different equivalent gestational ages of human neonatal brain not only aids in understanding this highly ordered process, but also provides clues to detect abnormalities caused by genetic or environmental factors. Cerebral vascular measurements offer important information on cerebral metabolism. However, either anatomical or functional studies of human brain development during this period are surprisingly scarce. Diffusion tensor imaging (DTi), a recently developed technology of magnetic resonance imaging (MRi), is capable of noninvasively delineating macroscopic anatomical components with high contrast and revealing structures at the microscopic level. Cerebral vascular quantification including cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRo2) can also be obtained through noninvasive MRi, specifically arterial spin labeling (aSL) and T2-relaxation under spin tagging (TRuST) MRi. in this proposed study, the structure and function of neonatal brain will be explored using noninvasive MRi technologies. 102 infants will be recruited and no sedation will be applied during MRi. The resultant database will provide reference standards for diagnostic radiology of premature newborns and reveal the vascular activities of these newborn brains. Specifically, three aims will be achieved: 1. To delineate the anatomical development of complex structure in the cerebral wall and white matter tracts of neonatal brains at different equivalent gestational ages. 2. To quantify the cerebral blood flow and metabolic rate of oxyg
Interventions
- DEVICE MRI
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 102 participants |
| Start Date | 2012-02 |
| Est. Completion | 2018-08 |
What the finished NCT02170142 record still lists
NCT02170142 is an observational study that tracks outcomes without assigning an intervention. The registered 102 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which MRI is the first listed.
NCT02170142 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02170142 about?
NCT02170142 is a clinical study titled "Characterization of the Functional and Structural Development of the Human Neonatal Brain From 30 Wks to 45 Wks ga". The major goal of this project is to characterize the structural and functional development of cortical plate and white matter of the human neonatal brain from the equivalent 30 gestational weeks to 45 gestational weeks. The project is sponsored by niH R01MH092535. Furthermore, it is related to the ...
What is the current status of trial NCT02170142?
This trial is currently completed. The enrollment target is 102 participants. The study started on 2012-02. Estimated completion is 2018-08.
What interventions are being tested in trial NCT02170142?
The interventions under investigation include: MRI (DEVICE).
Who is sponsoring clinical trial NCT02170142?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
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