Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02154477 · ClinicalTrials.gov registry record · Phase 1
Effect of Intranasal Insulin on LH Concentrations in Man
A Phase 1 study of Hypogonadotropic Hypogonadism, sponsored by Texas Tech University Health Sciences Center.
- Completed
- Registry status
- Phase 1
- Development phase
- 14
- Enrollment target
- 1
- Study location
NCT02154477: Completed Phase 1 study of Hypogonadotropic Hypogonadism, sponsored by Texas Tech University Health Sciences Center.
NCT02154477 is a Phase 1 study of Hypogonadotropic Hypogonadism that has completed, run by Texas Tech University Health Sciences Center. The registered enrollment target is 14 participants, below the 124-participant average among 6 other Hypogonadotropic Hypogonadism trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02154477, a Phase 1 study of Hypogonadotropic Hypogonadism, has completed, sponsored by Texas Tech University Health Sciences Center.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 14 participants
- Enrollment target
- 1
- Study location
Study Summary
Over the last few years, studies have shown that men with type 2 diabetes sometimes develop a condition called hypogonadotrophic hypogonadism (HH). People with this condition produce little or no sex hormones. Obesity and metabolic syndrome are also associated with HH. Research suggests that insulin in the brain may benefit the glands that release these hormones. During this study, subjects will spray a small amount of insulin into their nose.This will increase insulin concentrations in the brain. The purpose of this study is to find out the effect of one dose of intranasal insulin on release of LH (a sex hormone) in obese diabetic men with HH.
Primary Outcome
Luteinizing hormone (LH) concentrations after intranasal insulin as compared to placebo (intranasal saline). This endpoint was measured in both arms
Conditions Studied
Interventions
- DRUG intranasal insulin
- DRUG placebo (intranasal saline)
Study Locations (1)
Texas
- TTTUHSC-Permian Basin - Odessa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2014-12 |
| Est. Completion | 2017-12 |
| Phase | Phase 1 |
What the finished NCT02154477 record still lists
NCT02154477 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 124-participant average among 6 other Hypogonadotropic Hypogonadism trials with a reported enrollment target (89% lower).
The record links to 1 condition, with Hypogonadotropic Hypogonadism appearing as the primary indexed condition, and to 2 interventions - of which intranasal insulin is the first listed.
NCT02154477 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT02154477 about?
NCT02154477 is a clinical study titled "Effect of Intranasal Insulin on LH Concentrations in Man". Over the last few years, studies have shown that men with type 2 diabetes sometimes develop a condition called hypogonadotrophic hypogonadism (HH). People with this condition produce little or no sex hormones. Obesity and metabolic syndrome are also associated with HH. Research suggests that insulin...
What is the current status of trial NCT02154477?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2014-12. Estimated completion is 2017-12.
What conditions does trial NCT02154477 study?
This clinical trial studies the following conditions: Hypogonadotropic Hypogonadism.
What interventions are being tested in trial NCT02154477?
The interventions under investigation include: intranasal insulin (DRUG), placebo (intranasal saline) (DRUG).
Who is sponsoring clinical trial NCT02154477?
This trial is sponsored by Texas Tech University Health Sciences Center, which has 76 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02154477 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypogonadotropic Hypogonadism
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Opioid Antagonism in Hypogonadotropic Hypogonadism
COMPLETED · Phase 1
-
Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant.
RECRUITING
-
Kisspeptin Administration Subcutaneously to Patients With IHH
RECRUITING · Phase 2
-
Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea
RECRUITING · Phase 2
-
The Molecular Basis of Inherited Reproductive Disorders
RECRUITING
-
Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting Conditions
COMPLETED · Phase 3
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02523092 · 14 participants · Phase 4
Use of CXCL9 as a Biomarker of Acthar Efficacy
- NCT04263285 · 14 participants · NA
Treatment of Depression Post-SCI
- NCT04743271 · 14 participants · NA
Food and Circadian Timing
- NCT05065671 · 14 participants · Phase 1
Microbiome Derived Metabolism and Pharmacokinetics
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia