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NCT02082418 · ClinicalTrials.gov registry record · NA
Effects of Alpha-lactalbumin Intake on Metabolic and Cognitive Functions in Elderly
A NA study, sponsored by Texas A&M University.
- Completed
- Registry status
- NA
- Development phase
- 59
- Enrollment target
NCT02082418 is a NA study that has completed, run by Texas A&M University. The registered enrollment target is 59 participants.
The verdict
NCT02082418, a NA study, has completed, sponsored by Texas A&M University.
- COMPLETED
- Registry status
- NA
- Development phase
- 59 participants
- Enrollment target
Study Summary
Aging modifies the metabolic pathway of the neurotransmitter serotonin by reducing the synthesis rate and increasing the breakdown rate of serotonin, possibly related to the observed enhanced sensitivity of the serotonergic pathway. Since serotonin plays a prominent role in neuropsychological functions such as anxiety, mood and memory, the enhanced sensitivity of the serotonergic pathway in aging can probably explain the fact that elderly are more vulnerable to develop cognitive deficits and depressive symptoms. Serotonin synthesis in brain is regulated by its precursor tryptophan (TRP). Because tryptophan is an essential amino acid, modifying the availability of tryptophan through dietary intake, can directly influence central serotonin metabolism and consequently affective and cognitive processes. The aim of this study is to test the hypothesis that an acute intake of whey protein with high levels of TRP such as alpha-lactalbumin can stabilize the metabolism of serotonin and subsequently enhance metabolic and cognitive functions in healthy older adults. The acute effects of this dietary protein will be investigated in subjects with mild cognitive impairment (MCI), or dementia, compared to control subjects in order to examine whether healthy older subject with MCI benefit more from the intake of alpha-lactalbumin and/or whey. The investigators will investigate if this meal can optimize serotonin metabolism by elevating plasma TRP levels and plasma TRP appearance and enhance splanchnic TRP extraction. In addition, the effects on mood and cognitive functions will be examined.
Interventions
- DIETARY_SUPPLEMENT Alpha-lactalbumin
- DIETARY_SUPPLEMENT Whey
- DIETARY_SUPPLEMENT Casein
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 59 participants |
| Start Date | 2014-04-02 |
| Est. Completion | 2016-12-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02082418
The ClinicalTrials.gov registry entry for NCT02082418 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 59 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Texas A&M University, which has 95 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Alpha-lactalbumin is the first listed.
NCT02082418 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02082418 about?
NCT02082418 is a clinical study titled "Effects of Alpha-lactalbumin Intake on Metabolic and Cognitive Functions in Elderly". Aging modifies the metabolic pathway of the neurotransmitter serotonin by reducing the synthesis rate and increasing the breakdown rate of serotonin, possibly related to the observed enhanced sensitivity of the serotonergic pathway. Since serotonin plays a prominent role in neuropsychological functi...
What is the current status of trial NCT02082418?
This trial is currently completed. It is a NA study. The enrollment target is 59 participants. The study started on 2014-04-02. Estimated completion is 2016-12-01.
What interventions are being tested in trial NCT02082418?
The interventions under investigation include: Alpha-lactalbumin (DIETARY_SUPPLEMENT), Whey (DIETARY_SUPPLEMENT), Casein (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT02082418?
This trial is sponsored by Texas A&M University, which has 95 total clinical trials registered on ClinicalTrials.gov.
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