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NCT01990547 · ClinicalTrials.gov registry record
Virtual Reality Therapy and Imaging in Combat Veterans With Blast Injury and Posttraumatic Stress Disorder
A clinical trial, sponsored by Walter Reed National Military Medical Center.
- Completed
- Registry status
- 88
- Enrollment target
NCT01990547: Completed study, sponsored by Walter Reed National Military Medical Center.
NCT01990547 is a clinical trial that has completed, run by Walter Reed National Military Medical Center. The registered enrollment target is 88 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01990547 has completed, sponsored by Walter Reed National Military Medical Center.
- COMPLETED
- Registry status
- 88 participants
- Enrollment target
Study Summary
The main purpose of this study is to determine whether functional magnetic resonance imaging (fMRI), can distinguish between service members with and without traumatic brain injury (TBI), as well as those with posttraumatic stress disorder (PTSD) who receive either virtual reality exposure therapy (VRET) or PTSD treatment other than exposure therapy. The investigators and other investigators have previously identified changes in function in multiple regions of the brain in combat veterans with PTSD, and the investigators have also seen that structural changes in the white matter associated with combat TBI are also linked with changes in function, and in turn with PTSD symptoms. However, the investigators need to confirm these findings in larger numbers, and also need to discern whether fMRI can distinguish if there is something significantly different about those who have PTSD after TBI vs. those in whom it does not follow a TBI. Finally, the investigators have previously demonstrated that exposure therapy ameliorates the functional changes in the brain induced by PTSD, but the investigators do not know if similar changes occur with other forms of therapy, so the investigators seek to compare the two directly. It is our expectation that the findings will better inform the choice of therapy for service members with combat-related PTSD, with or without TBI.
Primary Outcome
Functional MRI: Requires the exposure of subjects to various sensory stimuli while in the scanner, in order to assess the function of specific regions of the brain, by measuring the blood-oxygen-level-dependent (BOLD) signal. The Affective Stroop is a validated series of stimuli for distinguishing between those with PTSD and controls, that entails showing participants a variety of pictures (some neutral and some emotionally charged), and also asks them to distinguish between various number patte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 88 participants |
| Est. Completion | 2014-08 |
What the finished NCT01990547 record still lists
NCT01990547 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 88 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01990547 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01990547 about?
NCT01990547 is a clinical study titled "Virtual Reality Therapy and Imaging in Combat Veterans With Blast Injury and Posttraumatic Stress Disorder". The main purpose of this study is to determine whether functional magnetic resonance imaging (fMRI), can distinguish between service members with and without traumatic brain injury (TBI), as well as those with posttraumatic stress disorder (PTSD) who receive either virtual reality exposure therapy (...
What is the current status of trial NCT01990547?
This trial is currently completed. The enrollment target is 88 participants. Estimated completion is 2014-08.
Who is sponsoring clinical trial NCT01990547?
This trial is sponsored by Walter Reed National Military Medical Center, which has 48 total clinical trials registered on ClinicalTrials.gov.
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