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NCT01821781 · ClinicalTrials.gov registry record · Phase 2
Immune Disorder HSCT Protocol
A Phase 2 study of Chronic Granulomatous Disease and Severe Combined Immunodeficiency, sponsored by Washington University School of Medicine.
- Active
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT01821781: Active Phase 2 study of Chronic Granulomatous Disease and Severe Combined Immunodeficiency, sponsored by Washington University School of Medicine.
NCT01821781 is a Phase 2 study of Chronic Granulomatous Disease and Severe Combined Immunodeficiency that is active but no longer recruiting, run by Washington University School of Medicine. The registered enrollment target is 20 participants, below the 31-participant average among 10 other Chronic Granulomatous Disease trials with a reported enrollment target (35% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01821781, a Phase 2 study of Chronic Granulomatous Disease and Severe Combined Immunodeficiency, is active but no longer recruiting, sponsored by Washington University School of Medicine.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.
Conditions Studied
Interventions
- DRUG Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
Study Locations (1)
Missouri
- Washington University - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2013-04-29 |
| Est. Completion | 2026-04 |
| Phase | Phase 2 |
What the registry record for NCT01821781 still lists
NCT01821781 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 31-participant average among 10 other Chronic Granulomatous Disease trials with a reported enrollment target (35% lower).
The record links to 10 conditions, with Chronic Granulomatous Disease appearing as the primary indexed condition, and to 1 intervention - of which Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan is the first listed.
NCT01821781 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT01821781 about?
NCT01821781 is a clinical study titled "Immune Disorder HSCT Protocol". This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce...
What is the current status of trial NCT01821781?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2013-04-29. Estimated completion is 2026-04.
What conditions does trial NCT01821781 study?
This clinical trial studies the following conditions: Chronic Granulomatous Disease, Severe Combined Immunodeficiency, DiGeorge Syndrome, Wiskott-Aldrich Syndrome, Chediak-Higashi Syndrome.
What interventions are being tested in trial NCT01821781?
The interventions under investigation include: Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan (DRUG).
Who is sponsoring clinical trial NCT01821781?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01821781 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01821781's enrollment target sits among peer trials
20 6th of 10 higher than 4 of 10 other Chronic Granulomatous Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Granulomatous Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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