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NCT01786941 · ClinicalTrials.gov registry record · NA
Regulation of Branched-chain Amino Acid Metabolism in Pre-Diabetes
A NA study, sponsored by Duke University.
- Completed
- Registry status
- NA
- Development phase
- 132
- Enrollment target
NCT01786941: Completed NA study, sponsored by Duke University.
NCT01786941 is a NA study that has completed, run by Duke University. The registered enrollment target is 132 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (91% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01786941, a NA study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- NA
- Development phase
- 132 participants
- Enrollment target
Study Summary
Elevated circulating levels of certain amino acids (the building blocks of protein) are strongly associated with insulin resistance. This study will investigate the metabolism of these amino acids in individuals with normal glucose metabolism compared to overweight or obese pre-diabetic individuals. The purpose of this study is to determine how elevated levels of the branched-chain amino acids may contribute to the development of insulin resistance and ultimately diabetes. An additional purpose is to determine whether exercise or gastric bypass (GBP) surgery intervention can correct aberrations in branched-chain amino acid metabolism as insulin sensitivity improves. This information will be used to further our understanding of the development of insulin resistance and type 2 diabetes in at-risk populations and potentially improve clinical treatment of such conditions.
Primary Outcome
1. Lean Healthy Controls - Baseline only 2. Pre-Diabetic Group - Baseline and 6-months post the Aerobic and Resistance combined exercise training intervention 3. Gastric Bypass Group - Baseline and 3-months post Gastric Bypass surgery
Interventions
- OTHER Pre-Diabetes Group - 6-mo Aerobic and Resistance combined exercise training
- OTHER GBP Group - Non-diabetics intending to undergo Gastric Bypass surgery
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 132 participants |
| Start Date | 2012-06 |
| Est. Completion | 2013-12 |
| Phase | NA |
What the finished NCT01786941 record still lists
NCT01786941 is an interventional study that assigns participants to a tested intervention. The registered 132 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (91% lower).
The record links to 0 conditions, and to 2 interventions - of which Pre-Diabetes Group - 6-mo Aerobic and Resistance combined exercise training is the first listed.
NCT01786941 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01786941 about?
NCT01786941 is a clinical study titled "Regulation of Branched-chain Amino Acid Metabolism in Pre-Diabetes". Elevated circulating levels of certain amino acids (the building blocks of protein) are strongly associated with insulin resistance. This study will investigate the metabolism of these amino acids in individuals with normal glucose metabolism compared to overweight or obese pre-diabetic individuals....
What is the current status of trial NCT01786941?
This trial is currently completed. It is a NA study. The enrollment target is 132 participants. The study started on 2012-06. Estimated completion is 2013-12.
What interventions are being tested in trial NCT01786941?
The interventions under investigation include: Pre-Diabetes Group - 6-mo Aerobic and Resistance combined exercise training (OTHER), GBP Group - Non-diabetics intending to undergo Gastric Bypass surgery (OTHER).
Who is sponsoring clinical trial NCT01786941?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01786941's enrollment target sits among peer trials
132 729th of 2000 higher than 1,269 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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