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NCT01768663 · ClinicalTrials.gov registry record · Phase 1
A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects
A Phase 1 study, sponsored by Vertex Pharmaceuticals Incorporated.
- Completed
- Registry status
- Phase 1
- Development phase
- 80
- Enrollment target
NCT01768663: Completed Phase 1 study, sponsored by Vertex Pharmaceuticals Incorporated.
NCT01768663 is a Phase 1 study that has completed, run by Vertex Pharmaceuticals Incorporated. The registered enrollment target is 80 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01768663, a Phase 1 study, has completed, sponsored by Vertex Pharmaceuticals Incorporated.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 80 participants
- Enrollment target
Study Summary
The purpose of this study is to examine the drug-drug interaction effects of ciprofloxacin, itraconazole, and rifampin on the pharmacokinetics of lumacaftor in combination with ivacaftor as well as to evaluate the potential effects of lumacaftor in combination with ivacaftor on lung function.
Interventions
- DRUG Rifampin
- DRUG Itraconazole
- DRUG Ciprofloxacin
- DRUG Ivacaftor
- DRUG Lumacaftor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2013-01 |
| Phase | Phase 1 |
What the finished NCT01768663 record still lists
NCT01768663 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% higher).
The record links to 0 conditions, and to 5 interventions - of which Rifampin is the first listed.
NCT01768663 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01768663 about?
NCT01768663 is a clinical study titled "A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects". The purpose of this study is to examine the drug-drug interaction effects of ciprofloxacin, itraconazole, and rifampin on the pharmacokinetics of lumacaftor in combination with ivacaftor as well as to evaluate the potential effects of lumacaftor in combination with ivacaftor on lung function.
What is the current status of trial NCT01768663?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 80 participants. The study started on 2013-01.
What interventions are being tested in trial NCT01768663?
The interventions under investigation include: Rifampin (DRUG), Itraconazole (DRUG), Ciprofloxacin (DRUG), Ivacaftor (DRUG), Lumacaftor (DRUG).
Who is sponsoring clinical trial NCT01768663?
This trial is sponsored by Vertex Pharmaceuticals Incorporated, which has 191 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01768663's enrollment target sits among peer trials
80 672nd of 2000 higher than 1,305 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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