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NCT01759277 · ClinicalTrials.gov registry record · Phase 4

Femoral Versus Adductor Canal Continuous Peripheral Nerve Blocks for Knee Arthroplasty

A Phase 4 study, sponsored by University of California, San Diego.

Completed
Registry status
Phase 4
Development phase
80
Enrollment target

NCT01759277: Completed Phase 4 study, sponsored by University of California, San Diego.

NCT01759277 is a Phase 4 study that has completed, run by University of California, San Diego. The registered enrollment target is 80 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT01759277, a Phase 4 study, has completed, sponsored by University of California, San Diego.

COMPLETED
Registry status
Phase 4
Development phase
80 participants
Enrollment target

Study Summary

Patients typically experience moderate-to-severe pain following knee arthroplasty that is usually treated with a combination of oral and intravenous analgesics and enhanced by continuous peripheral nerve blocks. There are currently two locations to place a perineural catheter to provide analgesia following knee arthroplasty: a femoral nerve catheter and an adductor canal catheter. Both have been demonstrated to be effective following knee arthroplasty. However, it remains unknown if one location is superior to the other; or, more accurately, what the relative benefits are to each technique. While femoral CPNB has many benefits, one of the challenges of using this technique is that there is a decrease in quadriceps muscle strength which can be a limiting factor for rehabilitation. In contrast, the adductor canal catheter affects only the vastus medialis. This block may lessen block-induced quadriceps weakness following knee arthroplasty compared with a femoral infusion. The investigators hypothesize that compared with femoral perineural local anesthetic infusion, an adductor canal infusion is associated with a shorter time until four discharge criteria are met: (1) adequate analgesia; (2) independence from intravenous analgesics; (3) ability to ambulate 30 m; and (4) ability to stand, walk 3 m, and return to a sitting position without another's assistance.

Primary Outcome

Discharge readiness is the number of hours until meeting the following 4 criteria: (1) adequate analgesia (defined as pain less than 4 on a NRS of 0-10); (2) independence from intravenous analgesics; (3) ability to ambulate 30 m and (4) ability to stand, walk 3 m, and return to a sitting position without another's assistance.

Interventions

  • DRUG Control: Femoral perineural local anesthetic infusion
  • DRUG Experimental: Adductor Canal perineural local anesthetic infusion

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2012-12
Est. Completion 2014-09
Phase Phase 4
University of California, San Diego

775 total trials

What the finished NCT01759277 record still lists

NCT01759277 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (85% lower).

The record links to 0 conditions, and to 2 interventions - of which Control: Femoral perineural local anesthetic infusion is the first listed.

NCT01759277 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT01759277 about?

NCT01759277 is a clinical study titled "Femoral Versus Adductor Canal Continuous Peripheral Nerve Blocks for Knee Arthroplasty". Patients typically experience moderate-to-severe pain following knee arthroplasty that is usually treated with a combination of oral and intravenous analgesics and enhanced by continuous peripheral nerve blocks. There are currently two locations to place a perineural catheter to provide analgesia fo...

What is the current status of trial NCT01759277?

This trial is currently completed. It is a Phase 4 study. The enrollment target is 80 participants. The study started on 2012-12. Estimated completion is 2014-09.

What interventions are being tested in trial NCT01759277?

The interventions under investigation include: Control: Femoral perineural local anesthetic infusion (DRUG), Experimental: Adductor Canal perineural local anesthetic infusion (DRUG).

Who is sponsoring clinical trial NCT01759277?

This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT01759277's enrollment target sits among peer trials

80 946th of 2000 higher than 1,021 of 2,000 other Phase 4 trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT01759277, the US trial registry maintained by the National Library of Medicine. NCT01759277 (small enrollment · none site footprint · completed) retrieved and formatted by PlainTrial, see methodology.