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NCT01733485 · ClinicalTrials.gov registry record · Phase 1
Electrophilic Fatty Acid Derivatives in Asthma
A Phase 1 study of Asthma and Electrophilic Fatty Acids, sponsored by Sally E. Wenzel MD.
- Completed
- Registry status
- Phase 1
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT01733485: Completed Phase 1 study of Asthma and Electrophilic Fatty Acids, sponsored by Sally E. Wenzel MD.
NCT01733485 is a Phase 1 study of Asthma and Electrophilic Fatty Acids that has completed, run by Sally E. Wenzel MD. The registered enrollment target is 50 participants, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01733485, a Phase 1 study of Asthma and Electrophilic Fatty Acids, has completed, sponsored by Sally E. Wenzel MD.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
Asthma is an inflammatory disease, which means it causes swelling in the lungs to cause shortness of breath and/or wheezing. There are several asthma medications that help to reduce this problem. The objective of this research study is to characterize the presence of electrophilic fatty acids in the bronchial airway of subjects with controlled asthma at baseline and after treatment with Aspirin, Indomethacin, or no treatment at all. The presence of electrophilic fatty acids may indicate inflammation. Aspirin and Indomethacin are known to respectively increase and inhibit the formation of electrophilic fatty acids. By gaining a better understanding of how electrophilic fatty acids work and how they respond to different treatment, researchers hope to be able to find better ways to lessen airway inflammation in asthma in the future.
Primary Outcome
Patients undergo a baseline bronchoscopy, afterwhich they are randomized to 5 days of a)indomethacin, b) aspirin, c) nothing . After treatment, another bronchoscopy is done. Outcomes are determined after each bronchoscopy
Conditions Studied
Interventions
- DRUG Aspirin
- DRUG Indomethacin
Study Locations (1)
Pennsylvania
- University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2011-10 |
| Est. Completion | 2017-06 |
| Phase | Phase 1 |
What the finished NCT01733485 record still lists
NCT01733485 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Asthma appearing as the primary indexed condition, and to 2 interventions - of which Aspirin is the first listed.
NCT01733485 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT01733485 about?
NCT01733485 is a clinical study titled "Electrophilic Fatty Acid Derivatives in Asthma". Asthma is an inflammatory disease, which means it causes swelling in the lungs to cause shortness of breath and/or wheezing. There are several asthma medications that help to reduce this problem. The objective of this research study is to characterize the presence of electrophilic fatty acids in th...
What is the current status of trial NCT01733485?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 50 participants. The study started on 2011-10. Estimated completion is 2017-06.
What conditions does trial NCT01733485 study?
This clinical trial studies the following conditions: Asthma, Electrophilic Fatty Acids.
What interventions are being tested in trial NCT01733485?
The interventions under investigation include: Aspirin (DRUG), Indomethacin (DRUG).
Who is sponsoring clinical trial NCT01733485?
This trial is sponsored by Sally E. Wenzel MD, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01733485 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Asthma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01733485's enrollment target sits among peer trials
50 263rd of 374 higher than 106 of 374 other Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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