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NCT01725919 · ClinicalTrials.gov registry record · NA
Examining How Motor Rehabilitation Promotes Brain Reorganization Following Stroke, an MRI Study
A NA study, sponsored by Ohio State University.
- Completed
- Registry status
- NA
- Development phase
- 31
- Enrollment target
NCT01725919 is a NA study that has completed, run by Ohio State University. The registered enrollment target is 31 participants.
The verdict
NCT01725919, a NA study, has completed, sponsored by Ohio State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 31 participants
- Enrollment target
Study Summary
Constraint-induced movement therapy (CI therapy) is a highly efficacious treatment for residual motor disability in chronic stroke. Its effectiveness is believed to be due, at least in part, to the therapy's ability to aid the brain in "rewiring itself." For example, CI therapy produces increases in the amount of grey matter (the parts of the brain where neuron cell bodies are most closely clustered) in certain areas of the human brain (Gauthier et al., 2008). The cellular and molecular mechanisms that are responsible for this increase in grey matter volume are not known, however. Thus, it is unclear how the therapy helps brains "rewire" themselves. This study aims to better understand the timecourse and cellular/molecular nature of brain changes during CI therapy. Because there is currently no way to directly measure cellular/molecular changes in the brain noninvasively, this study will infer what is happening on a microstructural level using new MRI techniques (three dimensional pictures of the brain). For example, by charting the timecourse of grey matter changes during CI therapy, and cross-comparing this to what is known about the timecourses of different cellular/molecular processes, the investigators can gain a greater understanding of what cellular processes may be responsible for increases in grey matter. The investigators will gain additional information about which cellular processes are important for rehabilitation-induced improvement by measuring larger-scale changes (e.g., amount of blood flow through different brain areas) that accompany cellular changes. The investigators are hopeful that by better understanding how CI therapy can change the brain, the effectiveness of rehabilitation can be improved upon. For example, insight into the mechanisms of rehabilitation-induced brain change may suggest particular drug targets to increase brain plasticity. This study will help us better understand how the brain repairs itself after injury.
Interventions
- BEHAVIORAL CI therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2012-07 |
| Est. Completion | 2025-07-10 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01725919
The ClinicalTrials.gov registry entry for NCT01725919 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 31 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ohio State University, which has 552 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which CI therapy is the first listed.
NCT01725919 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01725919 about?
NCT01725919 is a clinical study titled "Examining How Motor Rehabilitation Promotes Brain Reorganization Following Stroke, an MRI Study". Constraint-induced movement therapy (CI therapy) is a highly efficacious treatment for residual motor disability in chronic stroke. Its effectiveness is believed to be due, at least in part, to the therapy's ability to aid the brain in "rewiring itself." For example, CI therapy produces increases in...
What is the current status of trial NCT01725919?
This trial is currently completed. It is a NA study. The enrollment target is 31 participants. The study started on 2012-07. Estimated completion is 2025-07-10.
What interventions are being tested in trial NCT01725919?
The interventions under investigation include: CI therapy (BEHAVIORAL).
Who is sponsoring clinical trial NCT01725919?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
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