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NCT01722006 · ClinicalTrials.gov registry record
Drug Effects on Preference and Reward
A clinical trial, sponsored by University of Chicago.
- Completed
- Registry status
- 103
- Enrollment target
NCT01722006 is a clinical trial that has completed, run by University of Chicago. The registered enrollment target is 103 participants.
The verdict
NCT01722006 has completed, sponsored by University of Chicago.
- COMPLETED
- Registry status
- 103 participants
- Enrollment target
Study Summary
Classical conditioning is widely used to study motivational properties of addictive drugs in animals, but has rarely been used in humans. Here, we are establishing a procedure suitable for studying the neurobiology and individual determinants of classical conditioning in humans. Healthy volunteers are randomly assigned to four groups that received methamphetamine or placebo in the presence of distinctive environmental cues under paired or unpaired conditions. During each session, subjects perform tasks known to activate the ventral striatum in fMRI studies. The tasks are performed in the presence of a distinctive context, consisting of a screen background image of a beach or of mountains, accompanied by corresponding sounds. Separate groups of subjects carry out the tasks under high or low reward conditions. Within each of the two reward conditions, one group (paired), receives methamphetamine (20 mg, oral) or placebo consistently associated with one of the contexts, while the other (unpaired) receives drug or placebo unrelated to context. A fifth group (paired) perform the tasks with contextual cues but in the absence of monetary incentives. Before and after conditioning, participants carry out a series of forced choice tasks, and change of preference over time was analyzed.
Interventions
- BEHAVIORAL Pairing condition
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 103 participants |
| Start Date | 2010-12 |
| Est. Completion | 2012-07 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01722006
The ClinicalTrials.gov registry entry for NCT01722006 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 103 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Chicago, which has 796 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Pairing condition is the first listed.
NCT01722006 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01722006 about?
NCT01722006 is a clinical study titled "Drug Effects on Preference and Reward". Classical conditioning is widely used to study motivational properties of addictive drugs in animals, but has rarely been used in humans. Here, we are establishing a procedure suitable for studying the neurobiology and individual determinants of classical conditioning in humans. Healthy volunteers a...
What is the current status of trial NCT01722006?
This trial is currently completed. The enrollment target is 103 participants. The study started on 2010-12. Estimated completion is 2012-07.
What interventions are being tested in trial NCT01722006?
The interventions under investigation include: Pairing condition (BEHAVIORAL).
Who is sponsoring clinical trial NCT01722006?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
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