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NCT01703481 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 in Adult Participants With Advanced or Refractory Solid Tumors or Lymphoma
A Phase 1 study, sponsored by Janssen Research & Development.
- Completed
- Registry status
- Phase 1
- Development phase
- 188
- Enrollment target
NCT01703481: Completed Phase 1 study, sponsored by Janssen Research & Development.
NCT01703481 is a Phase 1 study that has completed, run by Janssen Research & Development. The registered enrollment target is 188 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (213% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01703481, a Phase 1 study, has completed, sponsored by Janssen Research & Development.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 188 participants
- Enrollment target
Study Summary
The purpose of this study is to evaluate the safety, pharmacokinetics (study of what the body does to a drug), and pharmacodynamics (study of what a drug does to the body) of JNJ-42756493, a pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor, in adult participants with advanced or refractory solid tumors or lymphoma.
Primary Outcome
The maximum tolerated dose as determined in Part 1 of the study will be used as the recommended dose for Part 2, 3 and Part 4.
Interventions
- DRUG JNJ-42756493: Part 1
- DRUG JNJ-42756493: Part 2
- DRUG JNJ-42756493: Part 3
- DRUG JNJ-42756493: Part 4
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 188 participants |
| Start Date | 2012-06-15 |
| Est. Completion | 2017-07-05 |
| Phase | Phase 1 |
What the finished NCT01703481 record still lists
NCT01703481 is an interventional study that assigns participants to a tested intervention. The registered 188 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (213% higher).
The record links to 0 conditions, and to 4 interventions - of which JNJ-42756493: Part 1 is the first listed.
NCT01703481 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01703481 about?
NCT01703481 is a clinical study titled "A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 in Adult Participants With Advanced or Refractory Solid Tumors or Lymphoma". The purpose of this study is to evaluate the safety, pharmacokinetics (study of what the body does to a drug), and pharmacodynamics (study of what a drug does to the body) of JNJ-42756493, a pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor, in adult participants with advanced o...
What is the current status of trial NCT01703481?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 188 participants. The study started on 2012-06-15. Estimated completion is 2017-07-05.
What interventions are being tested in trial NCT01703481?
The interventions under investigation include: JNJ-42756493: Part 1 (DRUG), JNJ-42756493: Part 2 (DRUG), JNJ-42756493: Part 3 (DRUG), JNJ-42756493: Part 4 (DRUG).
Who is sponsoring clinical trial NCT01703481?
This trial is sponsored by Janssen Research & Development, which has 593 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01703481's enrollment target sits among peer trials
188 289th of 2000 higher than 1,711 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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