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NCT01658657 · ClinicalTrials.gov registry record · NA
A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension
A NA study, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- NA
- Development phase
- 17
- Enrollment target
NCT01658657: Completed NA study, sponsored by University of North Carolina, Chapel Hill.
NCT01658657 is a NA study that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 17 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01658657, a NA study, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- NA
- Development phase
- 17 participants
- Enrollment target
Study Summary
The purpose of this study is to investigate the effect of plasma renin activity-guided therapy for determining hypertension treatment. Plasma renin is an enzyme in your blood that can be measured to determine your hypertension subtype. Once the subtype is known, doctors can prescribe specific medications to target your specific hypertension subtype. This study will investigate whether targeting the specific hypertension subtype helps to achieve blood pressure control sooner and with fewer medications compared to a standard fixed dose combination therapy.
Primary Outcome
At each study visit (approximately every 30 days), participants' BP will be checked. If BP is controlled (\<140mmHG systolic and \<90mmHG diastolic), then current medication will continue. If BP is uncontrolled, medication will be revised every 30 days (up to 120) until BP control is achieved.
Interventions
- DRUG Amlodipine
- DRUG Lisinopril
- DRUG metoprolol
- DRUG Hydrochlorothiazide
- DRUG lisinopril/hydrochlorothiazide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2012-10 |
| Est. Completion | 2014-07 |
| Phase | NA |
What the finished NCT01658657 record still lists
NCT01658657 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 5 interventions - of which Amlodipine is the first listed.
NCT01658657 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01658657 about?
NCT01658657 is a clinical study titled "A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension". The purpose of this study is to investigate the effect of plasma renin activity-guided therapy for determining hypertension treatment. Plasma renin is an enzyme in your blood that can be measured to determine your hypertension subtype. Once the subtype is known, doctors can prescribe specific medica...
What is the current status of trial NCT01658657?
This trial is currently completed. It is a NA study. The enrollment target is 17 participants. The study started on 2012-10. Estimated completion is 2014-07.
What interventions are being tested in trial NCT01658657?
The interventions under investigation include: Amlodipine (DRUG), Lisinopril (DRUG), metoprolol (DRUG), Hydrochlorothiazide (DRUG), lisinopril/hydrochlorothiazide (DRUG).
Who is sponsoring clinical trial NCT01658657?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01658657's enrollment target sits among peer trials
17 1871st of 2000 higher than 130 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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