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NCT01640275 · ClinicalTrials.gov registry record · Phase 1
Markers of Alzheimers Disease After Propofol or Isoflurane Anesthesia
A Phase 1 study, sponsored by Duke University.
- Completed
- Registry status
- Phase 1
- Development phase
- 105
- Enrollment target
NCT01640275: Completed Phase 1 study, sponsored by Duke University.
NCT01640275 is a Phase 1 study that has completed, run by Duke University. The registered enrollment target is 105 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (75% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01640275, a Phase 1 study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 105 participants
- Enrollment target
Study Summary
Previous work in animal models suggests that inhalational anesthetic agents may accelerate Alzheimer's disease pathogenesis, but it is unclear to what extent this may happen in humans. Here, the investigators propose to measure Alzheimer's disease-related neural markers in the cerebrospinal fluid (CSF) of patients exposed to anesthesia while undergoing neurosurgical procedures that require lumbar drain placement. Patients will be randomized to either receive inhalation anesthesia with isoflurane or intravenous anesthesia with propofol. CSF and blood samples will each be collected at the induction of anesthesia, and then again ten and twenty-four hours later. CSF samples will be assayed for amyloid beta, tau, and other Alzheimer's disease-associated markers; blood samples will be assayed for serum inflammatory markers and used for genotyping studies. These studies should clarify the effect of common anesthetic agents on Alzheimer's disease related neural markers.
Interventions
- DRUG Propofol
- DRUG Isoflurane
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2012-03 |
| Est. Completion | 2015-03 |
| Phase | Phase 1 |
What the finished NCT01640275 record still lists
NCT01640275 is an interventional study that assigns participants to a tested intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (75% higher).
The record links to 0 conditions, and to 2 interventions - of which Propofol is the first listed.
NCT01640275 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01640275 about?
NCT01640275 is a clinical study titled "Markers of Alzheimers Disease After Propofol or Isoflurane Anesthesia". Previous work in animal models suggests that inhalational anesthetic agents may accelerate Alzheimer's disease pathogenesis, but it is unclear to what extent this may happen in humans. Here, the investigators propose to measure Alzheimer's disease-related neural markers in the cerebrospinal fluid (C...
What is the current status of trial NCT01640275?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 105 participants. The study started on 2012-03. Estimated completion is 2015-03.
What interventions are being tested in trial NCT01640275?
The interventions under investigation include: Propofol (DRUG), Isoflurane (DRUG).
Who is sponsoring clinical trial NCT01640275?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01640275's enrollment target sits among peer trials
105 533rd of 2000 higher than 1,465 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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