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COMPLETED Phase 1

A Study of Atezolizumab Administered in Combination With Bevacizumab and/or With Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

NCT01633970 · View on ClinicalTrials.gov ↗

Study Summary

This open-label, Phase Ib study that has six treatment arms is designed to assess the safety, pharmacology and preliminary efficacy of atezolizumab (MPDL3280A; an engineered anti-programmed death-ligand 1 \[PDL1\] antibody) administered with bevacizumab (Arm A) and with bevacizumab plus oxaliplatin, leucovorin, and 5-fluorouracil (5-FU) (FOLFOX) (Arm B), with carboplatin and paclitaxel (Arm C), with carboplatin and pemetrexed (Arm D), with carboplatin and nab-paclitaxel (Arm E), and with nab-paclitaxel (Arm F) in participants with locally advanced or metastatic solid tumors. The study includes dose escalation cohort for establishing the maximum tolerated dose (MTD) or maximum administered dose (MAD) and then expansion cohort will be initiated based on a selected dose level at or below the MTD or MAD.

Conditions Studied

Interventions

  • DRUG Bevacizumab
  • DRUG Carboplatin
  • DRUG Atezolizumab
  • DRUG Leucovorin
  • DRUG 5-FU

Study Locations (11)

Massachusetts

  • Massachusetts General Hospital. — Boston
  • Beth Israel Deaconess Med Ctr — Boston
  • Dana Farber Can Ins — Boston

North Carolina

  • Duke University Medical Center — Durham
  • Carolina BioOncology Institute; Can Therapy & Res Ctr — Huntersville

Colorado

  • University of Colorado Cancer Center — Aurora

Connecticut

  • Yale University — New Haven

District of Columbia

  • Georgetown University Medical Center Lombardi Cancer Center — Washington D.C.

Illinois

  • Uni of Chicago — Chicago

New York

  • Laura and ISAAC Perlmutter Cancer Center at NYU Langone. — New York

Tennessee

  • Sarah Cannon Research Inst. — Nashville

Trial Details

FieldValue
Enrollment Target 240 participants
Start Date 2012-07-11
Est. Completion 2020-02-26
Phase Phase 1

Sponsor

Genentech

206 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01633970

The ClinicalTrials.gov registry entry for NCT01633970 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 206 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Cancer appearing as the primary indexed condition, and to 5 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01633970 reports 11 study locations spanning 8 distinct geographic areas — top geographies include Massachusetts, North Carolina, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01633970 about?

NCT01633970 is a clinical study titled "A Study of Atezolizumab Administered in Combination With Bevacizumab and/or With Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors". This open-label, Phase Ib study that has six treatment arms is designed to assess the safety, pharmacology and preliminary efficacy of atezolizumab (MPDL3280A; an engineered anti-programmed death-ligand 1 \[PDL1\] antibody) administered with bevacizumab (Arm A) and with bevacizumab plus oxaliplatin,...

What is the current status of trial NCT01633970?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 240 participants. The study started on 2012-07-11. Estimated completion is 2020-02-26.

What conditions does trial NCT01633970 study?

This clinical trial studies the following conditions: Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01633970?

The interventions under investigation include: Bevacizumab (DRUG), Carboplatin (DRUG), Atezolizumab (DRUG), Leucovorin (DRUG), 5-FU (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01633970?

This trial is sponsored by Genentech, which has 206 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01633970 being conducted?

This trial has 11 study locations across Colorado, Connecticut, District of Columbia, Illinois, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial