Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01536249 · ClinicalTrials.gov registry record · Phase 1
Dexpramipexole and Cimetidine Drug Drug Interaction (DDI)
A Phase 1 study, sponsored by Knopp Biosciences.
- Completed
- Registry status
- Phase 1
- Development phase
- 14
- Enrollment target
NCT01536249: Completed Phase 1 study, sponsored by Knopp Biosciences.
NCT01536249 is a Phase 1 study that has completed, run by Knopp Biosciences. The registered enrollment target is 14 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (77% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01536249, a Phase 1 study, has completed, sponsored by Knopp Biosciences.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 14 participants
- Enrollment target
Study Summary
This study will assess the effect of cimetidine on the pharmacokinetics (PK) of dexpramipexole in healthy volunteer and evaluate the safety and tolerability of dexpramipexole when given with or without cimetidine. Additionally, this study will explore the influence of genetic variation on the PK of dexpramipexole when given with or without cimetidine.
Interventions
- DRUG Dexpramipexole
- DRUG Cimetidine plus Dexpramipexole
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2012-03 |
| Est. Completion | 2012-04 |
| Phase | Phase 1 |
What the finished NCT01536249 record still lists
NCT01536249 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (77% lower).
The record links to 0 conditions, and to 2 interventions - of which Dexpramipexole is the first listed.
NCT01536249 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01536249 about?
NCT01536249 is a clinical study titled "Dexpramipexole and Cimetidine Drug Drug Interaction (DDI)". This study will assess the effect of cimetidine on the pharmacokinetics (PK) of dexpramipexole in healthy volunteer and evaluate the safety and tolerability of dexpramipexole when given with or without cimetidine. Additionally, this study will explore the influence of genetic variation on the PK of ...
What is the current status of trial NCT01536249?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2012-03. Estimated completion is 2012-04.
What interventions are being tested in trial NCT01536249?
The interventions under investigation include: Dexpramipexole (DRUG), Cimetidine plus Dexpramipexole (DRUG).
Who is sponsoring clinical trial NCT01536249?
This trial is sponsored by Knopp Biosciences, which has 12 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01536249's enrollment target sits among peer trials
14 1844th of 2000 higher than 154 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02523092 · 14 participants · Phase 4
Use of CXCL9 as a Biomarker of Acthar Efficacy
- NCT04263285 · 14 participants · NA
Treatment of Depression Post-SCI
- NCT04743271 · 14 participants · NA
Food and Circadian Timing
- NCT05065671 · 14 participants · Phase 1
Microbiome Derived Metabolism and Pharmacokinetics
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia