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NCT01520454 · ClinicalTrials.gov registry record · NA
Effect of Increased Free Fatty Acids on Leptin Function
A NA study of Obesity and Leptin Resistance, sponsored by Beth Israel Deaconess Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 26
- Enrollment target
- 1
- Study location
NCT01520454 is a NA study of Obesity and Leptin Resistance that has completed, run by Beth Israel Deaconess Medical Center. The registered enrollment target is 26 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.
The verdict
NCT01520454, a NA study of Obesity and Leptin Resistance, has completed, sponsored by Beth Israel Deaconess Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
Obese people have elevated levels of the hormone leptin. Despite this, they seem to be resistant to the effects of this hormone, which usually regulates appetite and energy expenditure. This is similar to what happens with insulin levels in the obese. Furthermore, the way lipid ingestion versus lipid infusion may impact novel molecules secreted by tissues commonly affected in insulin resistant states such as liver and muscle have not yet been studied. The aim of the present study is to investigate the effect of oral vs. different doses of IV lipid administration on molecular parameters related to glucose and energy homeostasis using a randomized, placebo-controlled design. Additionally, we will examine how increased free fatty acids (FFAs) my impact intracellular leptin signaling such as the STAT3 pathway.
Conditions Studied
Interventions
- DRUG Saline
- DRUG Heparin
- DRUG Intralipid
- DIETARY_SUPPLEMENT Water
- DIETARY_SUPPLEMENT oral fat
Study Locations (1)
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2011-11 |
| Est. Completion | 2016-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01520454
The ClinicalTrials.gov registry entry for NCT01520454 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 26 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (97% lower). The listed sponsor is Beth Israel Deaconess Medical Center, which has 488 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 5 interventions - of which Saline is the first listed.
NCT01520454 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT01520454 about?
NCT01520454 is a clinical study titled "Effect of Increased Free Fatty Acids on Leptin Function". Obese people have elevated levels of the hormone leptin. Despite this, they seem to be resistant to the effects of this hormone, which usually regulates appetite and energy expenditure. This is similar to what happens with insulin levels in the obese. Furthermore, the way lipid ingestion versus lipi...
What is the current status of trial NCT01520454?
This trial is currently completed. It is a NA study. The enrollment target is 26 participants. The study started on 2011-11. Estimated completion is 2016-12.
What conditions does trial NCT01520454 study?
This clinical trial studies the following conditions: Obesity, Leptin Resistance.
What interventions are being tested in trial NCT01520454?
The interventions under investigation include: Saline (DRUG), Heparin (DRUG), Intralipid (DRUG), Water (DIETARY_SUPPLEMENT), oral fat (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01520454?
This trial is sponsored by Beth Israel Deaconess Medical Center, which has 488 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01520454 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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