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NCT01520454 · ClinicalTrials.gov registry record · NA
Effect of Increased Free Fatty Acids on Leptin Function
A NA study of Obesity and Leptin Resistance, sponsored by Beth Israel Deaconess Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 26
- Enrollment target
- 1
- Study location
NCT01520454: Completed NA study of Obesity and Leptin Resistance, sponsored by Beth Israel Deaconess Medical Center.
NCT01520454 is a NA study of Obesity and Leptin Resistance that has completed, run by Beth Israel Deaconess Medical Center. The registered enrollment target is 26 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01520454, a NA study of Obesity and Leptin Resistance, has completed, sponsored by Beth Israel Deaconess Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
Obese people have elevated levels of the hormone leptin. Despite this, they seem to be resistant to the effects of this hormone, which usually regulates appetite and energy expenditure. This is similar to what happens with insulin levels in the obese. Furthermore, the way lipid ingestion versus lipid infusion may impact novel molecules secreted by tissues commonly affected in insulin resistant states such as liver and muscle have not yet been studied. The aim of the present study is to investigate the effect of oral vs. different doses of IV lipid administration on molecular parameters related to glucose and energy homeostasis using a randomized, placebo-controlled design. Additionally, we will examine how increased free fatty acids (FFAs) my impact intracellular leptin signaling such as the STAT3 pathway.
Primary Outcome
The GLP-1 area under the curve (AUC) was calculated from baseline to six hours
Conditions Studied
Interventions
- DRUG Saline
- DRUG Heparin
- DRUG Intralipid
- DIETARY_SUPPLEMENT Water
- DIETARY_SUPPLEMENT oral fat
Study Locations (1)
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2011-11 |
| Est. Completion | 2016-12 |
| Phase | NA |
What the finished NCT01520454 record still lists
NCT01520454 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 5 interventions - of which Saline is the first listed.
NCT01520454 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT01520454 about?
NCT01520454 is a clinical study titled "Effect of Increased Free Fatty Acids on Leptin Function". Obese people have elevated levels of the hormone leptin. Despite this, they seem to be resistant to the effects of this hormone, which usually regulates appetite and energy expenditure. This is similar to what happens with insulin levels in the obese. Furthermore, the way lipid ingestion versus lipi...
What is the current status of trial NCT01520454?
This trial is currently completed. It is a NA study. The enrollment target is 26 participants. The study started on 2011-11. Estimated completion is 2016-12.
What conditions does trial NCT01520454 study?
This clinical trial studies the following conditions: Obesity, Leptin Resistance.
What interventions are being tested in trial NCT01520454?
The interventions under investigation include: Saline (DRUG), Heparin (DRUG), Intralipid (DRUG), Water (DIETARY_SUPPLEMENT), oral fat (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01520454?
This trial is sponsored by Beth Israel Deaconess Medical Center, which has 488 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01520454 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01520454's enrollment target sits among peer trials
26 897th of 1053 higher than 151 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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