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COMPLETED Phase 2

A Trial of Single Agent Axitinib as Maintenance Therapy for Patients With First Line Metastatic Colorectal Cancer (mCRC)

NCT01490866 · View on ClinicalTrials.gov ↗

Study Summary

This is a non-randomized, open-label, Phase II trial investigating axitinib as a single-agent maintenance therapy following standard first-line FOLFOX/bevacizumab therapy for patients with mCRC.

Conditions Studied

Interventions

  • DRUG Bevacizumab
  • DRUG Leucovorin
  • DRUG 5-Fluorouracil
  • DRUG Axitinib

Study Locations (12)

Florida

  • Florida Cancer Specialists-South — Fort Myers
  • Woodlands Medical Specialists — Pensacola
  • Florida Cancer Specialists-North — St. Petersburg

Indiana

  • Oncology Hematology of SW Indiana — Newburgh
  • Hope Cancer Center — Terre Haute

Arkansas

  • NEA Baptist Clinic — Jonesboro

Georgia

  • Northeast Georgia Medical Center — Gainesville

Michigan

  • Grand Rapids Oncology Program — Grand Rapids

Nebraska

  • Nebraska Methodist Hospital — Omaha

New Jersey

  • Atlantic Health System — Summit

Tennessee

  • Tennessee Oncology — Nashville

Trial Details

FieldValue
Enrollment Target 70 participants
Start Date 2012-01
Est. Completion 2015-07
Phase Phase 2

Sponsor

SCRI Development Innovations

63 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01490866

The ClinicalTrials.gov registry entry for NCT01490866 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is SCRI Development Innovations, which has 63 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Colorectal Cancer appearing as the primary indexed condition, and to 4 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01490866 reports 12 study locations spanning 9 distinct geographic areas — top geographies include Florida, Indiana, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01490866 about?

NCT01490866 is a clinical study titled "A Trial of Single Agent Axitinib as Maintenance Therapy for Patients With First Line Metastatic Colorectal Cancer (mCRC)". This is a non-randomized, open-label, Phase II trial investigating axitinib as a single-agent maintenance therapy following standard first-line FOLFOX/bevacizumab therapy for patients with mCRC.

What is the current status of trial NCT01490866?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 70 participants. The study started on 2012-01. Estimated completion is 2015-07.

What conditions does trial NCT01490866 study?

This clinical trial studies the following conditions: Colorectal Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01490866?

The interventions under investigation include: Bevacizumab (DRUG), Leucovorin (DRUG), 5-Fluorouracil (DRUG), Axitinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01490866?

This trial is sponsored by SCRI Development Innovations, which has 63 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01490866 being conducted?

This trial has 12 study locations across Arkansas, Florida, Georgia, Indiana, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial