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NCT01462227 · ClinicalTrials.gov registry record · NA
Effect of Naltrexone on Counterregulatory Mechanisms in Hypoglycemia
A NA study, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 17
- Enrollment target
NCT01462227: Completed NA study, sponsored by Yale University.
NCT01462227 is a NA study that has completed, run by Yale University. The registered enrollment target is 17 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01462227, a NA study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 17 participants
- Enrollment target
Study Summary
Insulin treatment often causes the blood glucose levels to fall too low. The body usually responds to low blood glucose levels by releasing hormones which act against the insulin to help correct the low blood glucose levels. However, this hormone response can be altered in people with diabetes. Currently there are no therapeutic agents that can be used to improve the recovery from hypoglycemia (low blood sugar). Naltrexone is a tablet used to help people who are addicted to alcohol or morphine-based drugs to remain drug and alcohol-free but it can also affect the levels of the hormones which are released during hypoglycemia. The aim of this study is to determine whether naltrexone can be used to improve and accelerate the recovery from hypoglycemia in patients with type 1 diabetes.
Primary Outcome
Glucose was measured in the blood throughout the hyperinsulinemic-hypoglycemic clamp study.
Interventions
- DRUG Naltrexone High Dose
- DRUG Naltrexone Low Dose
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2011-08 |
| Est. Completion | 2013-10 |
| Phase | NA |
What the finished NCT01462227 record still lists
NCT01462227 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Naltrexone High Dose is the first listed.
NCT01462227 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01462227 about?
NCT01462227 is a clinical study titled "Effect of Naltrexone on Counterregulatory Mechanisms in Hypoglycemia". Insulin treatment often causes the blood glucose levels to fall too low. The body usually responds to low blood glucose levels by releasing hormones which act against the insulin to help correct the low blood glucose levels. However, this hormone response can be altered in people with diabetes. Curr...
What is the current status of trial NCT01462227?
This trial is currently completed. It is a NA study. The enrollment target is 17 participants. The study started on 2011-08. Estimated completion is 2013-10.
What interventions are being tested in trial NCT01462227?
The interventions under investigation include: Naltrexone High Dose (DRUG), Naltrexone Low Dose (DRUG).
Who is sponsoring clinical trial NCT01462227?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01462227's enrollment target sits among peer trials
17 1871st of 2000 higher than 130 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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