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NCT01446913 · ClinicalTrials.gov registry record · NA
Sleep Apnea in TIA/Stroke: Reducing Cardiovascular Risk With Positive Airway Pressure
A NA study of Stroke and Transient Ischemic Attack, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 255
- Enrollment target
- 2
- Study locations
NCT01446913: Completed NA study of Stroke and Transient Ischemic Attack, sponsored by Yale University.
NCT01446913 is a NA study of Stroke and Transient Ischemic Attack that has completed, run by Yale University. The registered enrollment target is 255 participants, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (98% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01446913, a NA study of Stroke and Transient Ischemic Attack, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 255 participants
- Enrollment target
- 2
- Study locations
Study Summary
The goal of this study is to develop a novel study design to safely and ethically conduct a long-term randomized controlled trial among patients at high risk for both sleep apnea and cardiovascular events that will examine whether effective positive airway pressure(PAP) therapy reduces cardiovascular risk. Patients with transient ischemic attack(TIA) or stroke have a high prevalence of sleep apnea(60-80%), and they are at high risk of cardiovascular events(myocardial infarction, congestive heart failure, recurrent stroke, and cardiovascular death)in the first year post event, despite current prevent strategies. Therefore, the treatment of sleep apnea may represent a novel therapeutic target to reduce cardiovascular outcomes in this high risk population.
Primary Outcome
The homeostasis model assessment-estimated insulin resistance (HOMA-IR). HOMA IR change is one of the measures used to assess cardiovascular risk. HOMA-IR Index (measured by calculating - fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5.). The change from baseline up until the final measurement (up to 12 months) was assessed.
Conditions Studied
Interventions
- DEVICE Standard CPAP Intervention
- BEHAVIORAL Enhanced CPAP Intervention
Study Locations (2)
Connecticut
- Yale University - New Haven
Indiana
- University of Indiana - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 255 participants |
| Start Date | 2011-05 |
| Est. Completion | 2014-04 |
| Phase | NA |
What the finished NCT01446913 record still lists
NCT01446913 is an interventional study that assigns participants to a tested intervention. The registered 255 participants enrollment target is mid-sized for trials with a published cap, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Stroke appearing as the primary indexed condition, and to 2 interventions - of which Standard CPAP Intervention is the first listed.
NCT01446913 reports a single indexed study location in Connecticut, Indiana.
Frequently Asked Questions
What is clinical trial NCT01446913 about?
NCT01446913 is a clinical study titled "Sleep Apnea in TIA/Stroke: Reducing Cardiovascular Risk With Positive Airway Pressure". The goal of this study is to develop a novel study design to safely and ethically conduct a long-term randomized controlled trial among patients at high risk for both sleep apnea and cardiovascular events that will examine whether effective positive airway pressure(PAP) therapy reduces cardiovascula...
What is the current status of trial NCT01446913?
This trial is currently completed. It is a NA study. The enrollment target is 255 participants. The study started on 2011-05. Estimated completion is 2014-04.
What conditions does trial NCT01446913 study?
This clinical trial studies the following conditions: Stroke, Transient Ischemic Attack.
What interventions are being tested in trial NCT01446913?
The interventions under investigation include: Standard CPAP Intervention (DEVICE), Enhanced CPAP Intervention (BEHAVIORAL).
Who is sponsoring clinical trial NCT01446913?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01446913 being conducted?
This trial has 2 study locations across Connecticut, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Stroke
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01446913's enrollment target sits among peer trials
255 84th of 454 higher than 371 of 454 other Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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