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NCT01434043 · ClinicalTrials.gov registry record
Diagnostic Accuracy of Cardiac CT Perfusion Compared to PET Imaging
A clinical trial, sponsored by University of Washington.
- Completed
- Registry status
- 35
- Enrollment target
NCT01434043: Completed study, sponsored by University of Washington.
NCT01434043 is a clinical trial that has completed, run by University of Washington. The registered enrollment target is 35 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01434043 has completed, sponsored by University of Washington.
- COMPLETED
- Registry status
- 35 participants
- Enrollment target
Study Summary
This purpose of this research project is to test the diagnostic accuracy (i.e., sensitivity, specificity, positive and negative predictive value, and receiver operator curve area under the curve) of cardiac computed tomography (CT) perfusion as compared to the best non-invasive test of blood flow -- cardiac positron emission transmission (PET) perfusion imaging. The primary outcome of the study is to determine the CT perfusion technique with the highest overall diagnostic accuracy measured by the highest area under the receiver operator curve. The investigators will test 4 different CT perfusion techniques. (A) Qualitative, visual inspection of the contrast-enhanced CT images (B) Enhanced voxel distribution analysis (C) Rate of myocardial contrast enhancement analysis (D) Quantitative heart blood flow using a distributed 2-region analysis A second aim is to reduce the radiation dose needed to maintain CT perfusion diagnostic accuracy. Using the CT perfusion data, the investigators will model the minimal number of cardiac cycle radiation exposures needed to keep the diagnostic accuracy similar to the full data set. A third aim is to test the incremental diagnostic accuracy of CT angiography plus CT perfusion to identify regions of low blood flow as compared to PET perfusion alone.
Primary Outcome
Diagnostic performance includes sensitivity, specificity, positive and negative predictive values, and receiver operator curve area under the curve \[ROC AUC\]. The highest ROC AUC will be considered the best diagnostic performance and will be compared statisically using the c-statistic.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2011-09 |
| Est. Completion | 2019-12-31 |
What the finished NCT01434043 record still lists
NCT01434043 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 35 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01434043 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01434043 about?
NCT01434043 is a clinical study titled "Diagnostic Accuracy of Cardiac CT Perfusion Compared to PET Imaging". This purpose of this research project is to test the diagnostic accuracy (i.e., sensitivity, specificity, positive and negative predictive value, and receiver operator curve area under the curve) of cardiac computed tomography (CT) perfusion as compared to the best non-invasive test of blood flow --...
What is the current status of trial NCT01434043?
This trial is currently completed. The enrollment target is 35 participants. The study started on 2011-09. Estimated completion is 2019-12-31.
Who is sponsoring clinical trial NCT01434043?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
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