Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01328613 · ClinicalTrials.gov registry record
A Prospective Study of Postpartum Depression in Women With Major Depression
A clinical trial, sponsored by National Institute on Aging (NIA).
- Terminated
- Registry status
- 85
- Enrollment target
NCT01328613: Clinical Trial study, sponsored by National Institute on Aging (NIA).
NCT01328613 is a clinical trial that was terminated before completion, run by National Institute on Aging (NIA). The registered enrollment target is 85 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01328613 was terminated before completion, sponsored by National Institute on Aging (NIA).
- TERMINATED
- Registry status
- 85 participants
- Enrollment target
Study Summary
Background: \- Postpartum depression (PPD) is a serious syndrome that resembles a major depressive episode and occurs in 10% to 20% of all mothers in the year following delivery. Women with histories of major depressive disorder (MDD) are at an increased risk for PPD and recurrent PPD with subsequent pregnancies. One possible genetic vulnerability to depression and PPD in particular is the BDNF gene. BDNF is a protein that affects the growth and development of brain cells, including those that help to regulate mood. BDNF levels have been shown to be significantly lower in individuals with depression, including women. Researchers are interested in studying BDNF levels and hormones such as estrogen in pregnant women who have MDD and are at risk for developing PPD. Objectives: \- To study connections between the BDNF protein and hormonal levels in pregnant women who are at risk for developing postpartum depression. Eligibility: \- Women who are currently pregnant and have a history of major depressive disorder, and either are taking a selective serotonin reuptake inhibitor (SSRI) or are not taking an antidepressant. Design: * This study involves six visits over the course of 12 months, during the first, second, and third trimesters (if possible) as well as 1 week, 1 month, and 3 months postpartum. Women will be allowed to participate at any point during pregnancy, but researchers are most interested in recruiting women who are in the first trimester. * Participants will be screened with a physical examination and medical history, blood samples, and questionnaires about their history of depressive episodes. * At each visit, participants will complete a number of questionnaires on depression symptoms, such as sleep disturbance and stress levels. Participants will also provide blood samples for hormone and other testing. * Participants who become depressed during the study will be referred to a treating psychiatrist or other professional for appropriate care and tr
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 85 participants |
| Start Date | 2007-11-09 |
| Est. Completion | 2014-09-29 |
Why NCT01328613 stopped before completion
NCT01328613 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 85 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01328613 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01328613 about?
NCT01328613 is a clinical study titled "A Prospective Study of Postpartum Depression in Women With Major Depression". Background: \- Postpartum depression (PPD) is a serious syndrome that resembles a major depressive episode and occurs in 10% to 20% of all mothers in the year following delivery. Women with histories of major depressive disorder (MDD) are at an increased risk for PPD and recurrent PPD with subseque...
What is the current status of trial NCT01328613?
This trial is currently terminated. The enrollment target is 85 participants. The study started on 2007-11-09. Estimated completion is 2014-09-29.
Who is sponsoring clinical trial NCT01328613?
This trial is sponsored by National Institute on Aging (NIA), which has 131 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00842283 · 85 participants
Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target
- NCT02133196 · 85 participants · Phase 2
T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer
- NCT03823144 · 85 participants · NA
Intravital Microscopy in Human Solid Tumors
- NCT03875638 · 85 participants · Phase 2
Treating Hyperexcitability in AD With Levetiracetam
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI